Objective:To observe the clinical efficacy of Jinbai Mixture in treating acute viral cough in children. Methods270 children patients with acute viral cough who met the observation standard were randomly divided into Jinbai Mixture group, Qingre Zhike group anjing (ambroxol hydrochloride and clenbuterol hydrochloride oral solution) group, who were treated with Jinbai Mixture,Qingre Zhike Oral Solution and Yitanjing respectively, with a course of 5 days. The quantitative indexes of symptom grading in children were observed and the clinical efficacy was evaluated, the changes on TCM syndrome score were observed before and after treatment,and the adverse medical events occurred in the treatment were recorded.  Results:Before treatment,there were no statistical differences in gender, age and course of disease among groups.The total clinical effective rates were 87.78% in the Jinbai Mixture group, 72.22% in the Qingre Zhike group and 52.87% in the Yitanjing group,respectively. The clinical control rate of the Jinbai Mixture group was obviously better than that of the Qingre Zhike group and Yitanjing group(P<0.01). The scores of TCM syndromes in all groups were decreased after treatment (P<0.01). The D-value of total score of TCM syndrome between treatment before and after in the Jinbai Mixture group was significantly higher than that in the Qingre Zhike group(P<0.05) andYitajing group(P<0.01), and the D-value of cough score and expectoration score in the Jinbai Mixture group were greater than those in the Qingre Zhike group andYitajing group(P<0.01). No adverse reactions were found in all groups.  Conclusion:Jinbai Mixture can significantly improve the clinical symptoms of cough and excessive phlegm in children with acute upper respiratory tract infection, and the clinical control rate is significant.