Efficacy observation of Modified Jinsu Pill in preventing and treating pediatric febrile convulsion:A clinical study of 180 cases

GUO Dachang; LI Zhan; NI Juxiu; GU Shenfeng; XU Li; SHEN Jiaying

doi:10.16305/j.1007-1334.2018.12.016

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Efficacy observation of Modified Jinsu Pill in preventing and treating pediatric febrile convulsion:A clinical study of 180 cases

更新时间：2022-08-31

- Efficacy observation of Modified Jinsu Pill in preventing and treating pediatric febrile convulsion:A clinical study of 180 cases
- Shanghai Journal of Traditional Chinese Medicine Vol. 52, Issue 12, Pages: 59-61(2018)
- 作者机构：
  
  1. 上海市静安区中心医院,复旦大学附属华山医院静安分院)中医儿科,上海,200040
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2018.12.016
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GUO Dachang, LI Zhan, NI Juxiu, et al. Efficacy observation of Modified Jinsu Pill in preventing and treating pediatric febrile convulsion:A clinical study of 180 cases. [J]. Shanghai Journal of Traditional Chinese Medicine 52(12):59-61(2018)
DOI：

GUO Dachang, LI Zhan, NI Juxiu, et al. Efficacy observation of Modified Jinsu Pill in preventing and treating pediatric febrile convulsion:A clinical study of 180 cases. [J]. Shanghai Journal of Traditional Chinese Medicine 52(12):59-61(2018) DOI： 10.16305/j.1007-1334.2018.12.016.

摘要

目的：观察加味金粟丹对小儿高热惊厥的防治作用。方法：将250例高热惊厥患儿分为治疗组(180例)与对照组(70例)。对照组发作期予常规西药治疗,缓解期不予干预。治疗组发作期西药治疗结束2周后服用加味金粟丹。两组疗程均为2个半月、随访1年,观察综合疗效,比较高热惊厥的复发率、最低惊厥体温及脑电图异常率的情况。结果：①最终完成试验者228例,其中治疗组165例,对照组63例。②治疗组、对照组有效率分别为69.7%、54.0%；组间综合疗效比较,差异有统计学意义,治疗组明显优于对照组(P＜0.05)。③组间惊厥复发率比较,差异有统计学意义,治疗组明显低于对照组(P＜0.05)。④再次发生惊厥的患儿中,随访期间与治疗前组内比较,两组最低惊厥体温差异均有统计学意义,均明显升高(P＜0.05)；但组间最低惊厥体温比较,差异无统计学意义(P＞0.05)。⑤随访1年后,治疗组、对照组的脑电图异常率分别为9.5%、21.3%,组间脑电图异常率比较差异有统计学意义,治疗组明显低于对照组(P＜0.05)。结论：加味金粟丹对于小儿高热惊厥的复发具有一定的预防作用,且对高热惊厥所致脑部损伤有一定的预防作用。

Abstract

Objective:To observe the preventive and therapeutic effects of Modified Jinsu Pill on pediatric febrile convulsion (FC). Methods250 children patients with febrile convulsion were randomly divided into the treatment group (180 cases) and control group (70 cases). The control group was treated with routine western medicine in acute stage and no intervention in remission stage, the treatment group was treated with Modified Jinsu Pill two weeks after the therapy of routine western medicine in acute stage, with a treatment course of 2.5 months and follow-up of 1 year. The comprehensive efficacy was observed. The recurrence rate of febrile convulsion, the lowest temperature inducing FC and the abnormity rate of encephalogram (ECG) were compared. Results:①Finally 228 cases completed the trial, among 165 cases in the treatment group and 63 cases in the control group. ②The effective rates were 69.7% in the treatment group and 54.0% in the control group. The comprehensive efficacy of the treatment group was better than that of the control group, with statistically significant difference (P<0.05). ③The recurrence rate of convulsion in the treatment group was obviously lower than that in the control group, with statistically significant difference (P<0.05). ④Among the patients with recurrence convulsion, compared between treatment before and follow-up, there was statistically significant difference on the lowest temperature inducing FC in both groups, and the temperature was obviously increased in both groups (P<0.05). However, during the follow-up, there was no statistically significant difference on the lowest temperature inducing FC between the two groups (P>0.05). ⑤After follow-up for one year, the abnormity rates of ECG were 9.5% in the treatment group and 21.3% in the control group, the abnormity rate of ECG of the treatment group was obviously lower than that of the control group, with statistically significant difference (P<0.05). Conclusion:Modified Jinsu Pill exerts certain preventive effects on the recurrence of pediatric febrile convulsion, as well as the brain damage induced by febrile convulsion.

关键词

高热惊厥小儿加味金粟丹复发率最低惊厥体温脑电图癫痫

Keywords

febrile convulsionpediatricModified Jinsu Pillrecurrence ratelowest temperature inducing febrile convulsionencephalogramepilepsy

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