Objective:To observe the clinical efficacy of Chinese medicine physical and breathing exercise for calculi removal combined with Zhou’s calculi removal decoction (drug-exercise combination therapy) in the treatment of upper urinary tract calculi with syndrome of dampness-heat diffused downward. Methods158 patients of upper urinary tract calculi with syndrome of dampness-heat diffused downward were randomly divided into the treatment group and the control group, 79 cases in each group. The treatment group was treated with Zhou’s calculi removal decoction combined with Chinese medicine physical and breathing exercise forcalculi removal (drug-exercise combination therapy), and the control group was treated with Zhou’s calculi removal decoction, with a course of 1 month. The clinical efficacy and medication safety were observed, and the changes of TCM syndrome score and symptom scores were compared.  Results:①Finally 150 patients completed the trial, among 75 cases in the treatment group and 75 cases in the control group. ②The total effective rates were 68.0% in the treatment group and 60.0% in the control group. The clinical efficacy of the treatment group was obviously better than that of the control group (P<0.05). ③In both groups, there were statistically significant differences on the TCM syndrome score and symptom scores between treatment before and after (P<0.05). After treatment, the TCM syndrome score in the treatment group was significantly lower than that in the control group (P<0.05). The scores of urethral burning, frequent urination and urgent urination in the treatment group were significantly lower than those in the control group (P<0.05). However, there were no statistically significant differences on the scores of lumbago, hematuresis, urination pain and lower abdominal pain between the two groups (P>0.05).  Conclusion:Chinese medicine physical and breathing exercise for calculi removal combined with Zhou’s calculi removal decoction (drug-exercise combination therapy) is safe and effective in the treatment of upper urinary tract calculi with syndrome of dampness-heat diffused downward, and its efficacy is better than Chinese medicine alone, which can remarkably improve the clinical symptoms, accelerate the calculi expulsion, and relieve the pain of patients.