This paper discusses Professor Lyu Xiong’s experience in treating diabetic skin pruritus with therapy of harmonizing liver and spleen. It is believed that long-term diabetes can cause disorder of visceral-qi and disharmony between liver and spleen,which induces turbid toxin. Stagnation of turbid toxin transforms into heat,and the heat transmits through the skin meridians,which leads to skin pruritus. The treatment is based on dispersing stagnated liver qi and clearing heat and resolving turbidity. Modified Shuhe Drink can be used. And one proven case is presented.