This paper analyzes Chen Jianjie’s clinical experience in treating chronic hepatitis B with herbal paste. It is considered that the prescriptions should be in accordance with seasonal conditions,local conditions and patient’s individuality,and the medication should be cautious. The treatment should be regulating liver as key and combined with,spleen and kidney,which is based on harmony and takes reinforcement and elimination in combination. The accompanying symptoms can not be neglected and can be treated combined with main syndrome. And one proven case is presented.