This paper introduces Professor Xu Rongjuan’s clinical experience in treating diabetes insipidus with therapy of clearing upper energizer and warming lower energizer. It is considered that heat in upper energizer and cold in lower energizer are the primary pathogenesis of diabetes insipidus. The treatment should be based on clearing dryness-heat in the lung and stomach and warming deficient yang in kidney,which can combine with various warming yang methods,such as warming and astringing,warming and nourishing yin,warming and suppressing yang, warming and tonifying qi,warming and resolving dampness,warming and reconciling Shaoyang disorder. The commonly used drugs include Shigao(Gypsum Fibrosum),Zhimu(Anemarrhenae Rhizoma),Huanglian(Coptidis Rhizoma),Shanyao(Dioscoreae Rhizoma),Fuzi(Aconiti Lateralis Preparata Radix)and so on. One proven case is presented.