Optimization on extraction process of Compound Baizhi Zhitong Capsule based on information entropy theory and fingerprint

HUANG Guangwei; YANG Sude; CAO Jingdi

doi:10.16305/j.1007-1334.2018.11.021

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Optimization on extraction process of Compound Baizhi Zhitong Capsule based on information entropy theory and fingerprint

更新时间：2022-08-31

- Optimization on extraction process of Compound Baizhi Zhitong Capsule based on information entropy theory and fingerprint
- Shanghai Journal of Traditional Chinese Medicine Vol. 52, Issue 11, Pages: 80-85(2018)
- 作者机构：
  
  1. 上海绿谷生命园医药有限公司,上海,201707
  2. 上海复方中药,绿谷)工程技术研究中心,上海,201707
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2018.11.021
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HUANG Guangwei, YANG Sude, CAO Jingdi. Optimization on extraction process of Compound Baizhi Zhitong Capsule based on information entropy theory and fingerprint. [J]. Shanghai Journal of Traditional Chinese Medicine 52(11):80-85(2018)
DOI：

HUANG Guangwei, YANG Sude, CAO Jingdi. Optimization on extraction process of Compound Baizhi Zhitong Capsule based on information entropy theory and fingerprint. [J]. Shanghai Journal of Traditional Chinese Medicine 52(11):80-85(2018) DOI： 10.16305/j.1007-1334.2018.11.021.

摘要

目的：以正交试验结合指纹图谱和信息熵综合评价,优选复方白芷止痛胶囊的提取工艺。方法：通过正交试验,选择绿原酸、阿魏酸、欧前胡素、异欧前胡素的提取率,浸膏得率结合指纹图谱相似度作为综合评价指标,采用信息熵赋权法确定各指标的客观权重,实现对提取工艺的正交试验优选。结果：最佳提取工艺为以10倍量70%乙醇提取3次,每次1 h。结论：以正交试验结合指纹图谱和信息熵综合评价优选提取工艺,专属性强、灵敏度高,可用于中药复方提取工艺优选。

Abstract

Objective:To optimize the extraction process parameters of Compound Baizhi Zhitong Capsule on the basis of orthogonal test combined with fingerprint and information entropy as comprehensive evaluation. MethodsOrthogonal test was conducted to determine the extraction ratio, extract yield and fingerprint similarity of chlorogenic acid, ferulic acid, imperatorin, isoimperatorin as comprehensive evaluation indexes. Information entropy method was used to determine the objective weight of each index to achieve the orthogonal test optimization on extraction process. Results:The optimum extraction process were as follows: extraction with 70% alcohol at 10 times amount of the drug weight for three times, each time for one hour. Conclusion:The optimization of extraction process on the basis of orthogonal test combined fingerprint and information entropy can be used for optimizing the extraction process of Compound Chinese medicine, with high specificity and sensitirity.

关键词

信息熵正交试验指纹图谱阿魏酸绿原酸欧前胡素异欧前胡素

Keywords

information entropyorthogonal testfingerprintferulic acidchlorogenic acidimperatorinisoimperatorin

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