Objective:To observe the effects of Biling Qutong Prescription, with effects of eliminating turbid, detoxification and dredging collaterals, on FOXOL and VCAM-1 and renal pathology in model rat of diabetic gout. Methods50 healthy male rats were selected. Except the normal group, the rats in the other groups were fed with high-fat diet and treated with low-dose streptozotocin (35 mg/kg) by one-time intraperitoneal injection, the blood glucose level equal or greater than 16.7 mmol/L was considered as the diabetes model. After 4 days, 5% sodium urate solution was injected into the joint cavity to induce the gout model. After successful modeling, the Biling Qutong Prescription group, indomethacin group and pioglitazone group were treated with the correspending drugs for 21 days. The normal group and the model group were treated with 0.9% NaCl solution at equivalent volume. After 21 days, the blood was collected to detect FOXOL, VCAM-1, Cys-C, PG, UA and LDL-C, and the kidneys were collected to observe the pathological changes.  Results:Compared with the normal group, the FOXOL, VCAM-1 and Cys-C were significantly increased in the model group (P<0.01). After drug treatment, the above indexes in all drug treatment groups were significantly decreased (P<0.01), and the above indexes in the Biling Qutong Prescription group were superior to those in the pioglitazone group (P<0.05, P<0.01). Compared with the normal group, the plasma glucose and LDL-C in the model group were significantly increased (P<0.01). After intragastric administration, the plasma glucose and LDL-C in the drug treatment groups were decreased significantly (P<0.01). After modeling, the blood UA and Scr were significantly increased in the model group (P<0.01), and after drug treatment, the serum uric acid was decreased in all drug treatment groups (P<0.01). The Scr level was decreased in the Biling Qutong Prescription group (P<0.05). Correlation analysis showed that hyperglycemia was associated with hyperuricemia (r=0.42, P<0.05). Pathological reports showed that there were tubulointerstitial hyperemia and swelling, vacuolar degeneration and lots of inflammatory cells infiltration in the model group. After the treatment with Biling Qutong Prescription, the lesion degree was significantly reduced, and there was a small amount of inflammatory cell infiltration in the renal tubules.  Conclusion:There is a correlation between hyperglycemia and hyperuricemia. Biling Qutong Prescription, with effects of eliminating turbid, detoxification and dredging collaterals, shows good hypoglycemic effect as well as decreasing uric acid and LDL-C, which can significantly down-regulate the high expressions of FOXOL, VCAM-1 and Cys-C, and reduce the influence of inflammatory factors on renal pathology.