Clinical study on effects of transcutaneous electrical acupoint stimulation sequential therapy on infertile patients undergoing in vitro fertilization-embryo transfer

DONG Guangping; WANG Jing; ZHOU Juan; YAN Hua

doi:10.16305/j.1007-1334.2018.11.015

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Clinical study on effects of transcutaneous electrical acupoint stimulation sequential therapy on infertile patients undergoing in vitro fertilization-embryo transfer

更新时间：2022-08-31

- Clinical study on effects of transcutaneous electrical acupoint stimulation sequential therapy on infertile patients undergoing in vitro fertilization-embryo transfer
- Shanghai Journal of Traditional Chinese Medicine Vol. 52, Issue 11, Pages: 54-57(2018)
- 作者机构：
  
  1. 上海中医药大学研究生院,上海,201203
  2. 上海中医药大学附属曙光医院生殖医学科,上海,201203
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2018.11.015
  CLC：
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DONG Guangping, WANG Jing, ZHOU Juan, et al. Clinical study on effects of transcutaneous electrical acupoint stimulation sequential therapy on infertile patients undergoing in vitro fertilization-embryo transfer. [J]. Shanghai Journal of Traditional Chinese Medicine 52(11):54-57(2018)
DOI：

DONG Guangping, WANG Jing, ZHOU Juan, et al. Clinical study on effects of transcutaneous electrical acupoint stimulation sequential therapy on infertile patients undergoing in vitro fertilization-embryo transfer. [J]. Shanghai Journal of Traditional Chinese Medicine 52(11):54-57(2018) DOI： 10.16305/j.1007-1334.2018.11.015.

摘要

目的：观察经皮穴位电刺激(TEAS)序贯疗法干预行体外受精-胚胎移植的不孕患者的临床疗效。方法：将83例患者随机分为治疗组(42例)与对照组(41例)。对照组予西药拮抗剂促排方案,治疗组予西药拮抗剂促排方案+TEAS序贯疗法。两组均在拮抗剂促排方案常规周期后,比较促排药物用量及促排药物干预时间、胚胎发育相关指标(卵子受精率、卵裂率、优胚率)、妊娠相关指标(生化妊娠率、临床妊娠率、胚胎着床率)的变化情况。结果：①最终完成试验者80例,治疗组40例,对照组40例；最终符合鲜胚移植条件者治疗组15例,对照组14例。②疗程期间,治疗组促排药物用量明显少于对照组(P<0.05)。两组促排干预时间比较,差异无统计学意义(P>0.05)。③疗程期间,治疗组优胚率明显高于对照组(P<0.05)。两组卵子受精率、卵裂率比较,差异无统计学意义(P>0.05)。④随访发现,治疗组生化妊娠率、临床妊娠率及胚胎着床率存在高于对照组的趋势,但本研究中差异尚无统计学意义(P>0.05)。结论：TEAS序贯疗法联合西药拮抗剂促排方案,干预行IVF-ET的不孕患者,疗效优于单用西药方案,尤其在减少患者促排药物用量及提高优胚率方面优势明显。

Abstract

Objective:To observe the clinical efficacy of transcutaneous electrical acupoint stimulation (TEAS) sequential therapy on infertile patients undergoing in vitro fertilization-embryo transfer. MethodsEighty-three patients were randomly divided into the treatment group (42 cases) and control group (41 cases). The control group was treated with promotion program of western medicine antagonist, and the treatment group was treated with promotion program of western medicine antagonist plus TEAS sequential therapy. After the regular cycle of antagonist promotion regimen, the changes on dose of promoting drugs, intervention time of promoting drugs, embryo development related indicators (ovum fertilization rate, cleavage rate and excellent embryo rate), pregnancy related indicators (biochemical pregnancy rate, clinical pregnancy rate and embryo implantation rate) were compared. Results:①Finally, 80 patients including 40 patients in the treatment group and 40 patients in the control group completed the trial. There were 15 patients in the treatment group and 14 patients in the control group who met the condition of fresh embryo transfer. ②During the course of treatment, the dosage of promoting drugs in the treatment group was significantly less than that in the control group (P<0.05). There was no statistically significant difference on the intervention time of promoting drugs between the two groups (P>0.05). ③During the course of treatment, the rate of excellent embryos in the treatment group was significantly higher than that in the control group (P<0.05). There were no statistically significant differences on the ovum fertilization rate and cleavage rate between the two groups (P>0.05). ④During the follow-up, the biochemical pregnancy rate, clinical pregnancy rate and embryo implantation rate in the treatment group were higher than those in the control group, but with no statistically significant differences (P>0.05). Conclusion:The efficacy of TEAS sequential therapy combined with western medicine antagonist promotion program on the infertile patients undergoing IVF-ET is better than western medicine alone, especially in reducing the dosage of promoting drugs and improving the rate of excellent embryos.

关键词

不孕症体外受精-胚胎移植经皮穴位电刺激序贯治疗拮抗剂促排卵

Keywords

infertilityin vitro fertilization-embryo transfertranscutaneous electrical acupointsequential therapyantagonist promoting ovulation

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