Effects of elemene on quality of life of patients with advanced cancer: A Meta-analysis

LI Chenxi; ZENG Yiying; ZHAI Bingtao; ZHANG Nana; ZENG Yijun; ZENG Zhaowu; XIE Tian

doi:10.16305/j.1007-1334.2018.10.004

您当前的位置：

首页 >

文章列表页 >

Effects of elemene on quality of life of patients with advanced cancer: A Meta-analysis

更新时间：2022-08-31

- Effects of elemene on quality of life of patients with advanced cancer: A Meta-analysis
- Shanghai Journal of Traditional Chinese Medicine Vol. 52, Issue 10, Pages: 17-24(2018)
- 作者机构：
  
  1. 杭州师范大学整合药学院,浙江省榄香烯类抗癌中药研究重点实验室,浙产中药材资源开发与应用浙江省工程实验室,浙江,杭州,310036
  2. 成都中医药大学药学院,四川,成都,611137
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2018.10.004
  CLC：
扫描看全文
LI Chenxi, ZENG Yiying, ZHAI Bingtao, et al. Effects of elemene on quality of life of patients with advanced cancer: A Meta-analysis. [J]. Shanghai Journal of Traditional Chinese Medicine 52(10):17-24(2018)
DOI：

LI Chenxi, ZENG Yiying, ZHAI Bingtao, et al. Effects of elemene on quality of life of patients with advanced cancer: A Meta-analysis. [J]. Shanghai Journal of Traditional Chinese Medicine 52(10):17-24(2018) DOI： 10.16305/j.1007-1334.2018.10.004.

摘要

目的：系统评价榄香烯对晚期肿瘤患者生活质量的影响。方法：利用计算机检索PubMed数据库、中国知网数据库、万方数据库、维普中文期刊全文数据库、web of science数据库,选择化疗结合榄香烯(治疗组)对比单纯化疗(对照组)治疗晚期肿瘤患者的相关随机对照试验(RCT)文献；对纳入的文献进行资料提取和质量评价,采用RevMan5.3软件进行Meta分析,比较两组患者生活质量的疗效和安全性。结果：①=1\*GB3共纳入20个RCT。②=2\*GB3治疗组患者的生活质量稳定率[OR=2.87,95% CI(2.28,3.61),P<0.000 1]和生活质量改善率[OR=2.89,95% CI(2.32,3.75),P<0.000 1]明显高于对照组。③=3\*GB3治疗组白细胞抑制发生率[OR=0.40,95% CI(0.29,0.55),P<0.000 1]、血小板抑制发生率 [OR=0.50,95% CI(0.36,0.69),P<0.000 1]和胃肠道反应发生率[OR=0.64,95% CI(0.49,0.84),P=0.001]低于对照组,发热反应发生率[OR=2.90,95% CI(1.62,5.22),P=0.000 4]高于对照组；两组肝功能损害发生率[OR=0.72,95% CI(0.45,1.15),P=0.17]、肾功能损害发生率[OR=0.48,95% CI(0.16,1.45),P=0.19]和静脉炎发生率[OR=2.45,95% CI(0.62,9.63),P=0.20]差异无统计学意义。结论：与单纯应用化疗比较,化疗结合榄香烯可以显著提高晚期肿瘤患者的生活质量,同时还可以降低骨髓抑制和胃肠道的不良反应。但榄香烯增加了患者发热的风险,临床应用时应根据患者的具体情况而定。

Abstract

Objective:To systematically evaluate the effects of elemene on quality of life in patients with advanced cancer. MethodsThe databases including China national knowledge infrastructure (CNKI), Wanfang, VIP Chinese periodical full-text and web of science were used to retrieve the randomized controlled trials (RCTs) involving chemotherapy combined with elemene treatment group (treatment group) and chemotherapy alone group (control group) in the treatment of advanced cancer. Data extraction and quality evaluation were conducted for the included documents. Meta-analysis was performed by RevMan 5.3 software. The efficacy and safety on improving the quality of life of patients in both groups were compared. Results:①A total of 20 RCTs were included. ②The stability rate of quality of life [OR=2.87,5% CI (2.28,3.61), P<0.000 1] and the improvement rate of quality of life [OR=2.89,5% CI (2.32,3.75), P<0.000 1] of patients in the treatment group were significantly higher than those in the control group. ③The incidence rate of leukocyte inhibition [OR=0.40,5% CI (0.29,0.55), P <0.000 1], the incidence rate of platelet inhibition [OR=0.50,5% CI (0.36,0.69), P<0.000 1] and the incidence rate of gastrointestinal reactions [OR=0.64,5% CI (0.49,0.84), P =0.001] in the treatment group were lower than those in the control group. However, the incidence rate of fever [OR=2.90, 95% CI (1.62,5.22), P =0.000 4] in the treatment group was higher than that in the control group. There were no statistically significant differences on the incidence rate of liver function damage [OR=0.72,5% CI (0.45,1.15), P=0.17], the incidence rate of kidney function damage [OR=0.48,5% CI (0.16, 1.45), P=0.19] and the incidence rate of phlebitis [OR=2.45,5% CI (0.62,9.63), P=0.20] between the two groups. Conclusion:Compared with chemotherapy alone, chemotherapy combined with elemene can not only significantly improve the quality of life of patients with advanced cancer, but also reduce the myelosuppression and gastrointestinal adverse reactions. However, the application of elemene increases the risk of fever in patients, so the specific clinical application should be applied according to the specific circumstances of patients.

关键词

晚期肿瘤榄香烯生活质量系统评价Meta分析

Keywords

advanced cancerelemenequality of lifesystematical evaluationMeta-analysis

references

Views

314

下载量

CSCD

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

Xuanhushangtong Tablets combined with celecoxib in promoting rapid rehabilitation after distal radius fractures

Meta⁃analysis of clinical efficacy of Xuefu Zhuyu Decoction for post⁃stroke depression

Meta⁃analysis of clinical efficacy of Chinese herbal formulas on obesity based on randomized controlled trials

Meta-analysis on efficacy and safety of Ginkgo Folium extract in treating diabetic kidney disease

Meta⁃analysis of efficacy and safety of Dachengqi Decoction combined with octreotide and conventional therapy for early postoperative inflammatory small bowel obstruction

Related Author

No data

Related Institution

Sichuan Province Orthopaecological Hospital

Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Tai’an Hospital of Traditional Chinese Medicine， Tai’an

Shandong University of Traditional Chinese Medicine， Ji’nan

Department of Endocrinology， Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

⁰