Objective:To observe the clinical efficacy of external washing recipe for eczema in treating infantile eczema with syndrome of excessive dampness-heat. Methods68 infants of eczema with syndrome of excessive dampness-heat were randomly divided into the treatment group and control group,34 cases in each group. The control group was treated with calamine lotion by external application,and the treatment group was treated with external washing recipe for eczema by wet compress,with a course of 14 days. The clinical efficacy was observed. The changes on eczema area and severity index (EASI) score and TCM syndrome score were compared.  Results:①The total effective rates were 94.1% in the treatment group and 76.5% in the control group. There was statistically significant difference on the clinical efficacy between the two groups,and the clinical efficacy of the treatment group was obviously better than that of the control group (P<0.05). ②In both groups,there were statistically significant differences on the ESAI score and TCM syndrome score between treatment before and after (P<0.05). After treatment,the ESAI score and TCM syndrome score in the treatment group were obviously lower than those in the control group (P<0.05). ③No adverse reactions such as redness,swollen and allergy were observed in the local drug-treated skin of patients in both groups.  Conclusion:Compared with calamine lotion,external washing recipe for eczema shows better efficacy in the treatment of infantile eczema with syndrome of excessive dampness-heat,which can alleviate the symptoms of skin pruritus and skin lesions,with no adverse reactions.