Comparative study on IL-1β level between deficiency and excess syndrome in patients with chronic hepatitis B

SHEN Guohui; WANG Yuejiao; SONG Haiyan; ZHANG Li; YANG Lili; CUI Tianbing; ZHANG Haiyan; YU Xiao; ZHENG Peiyong; JI Guang; XING Lianjun

doi:10.16305/j.1007-1334.2018.09.005

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Comparative study on IL-1β level between deficiency and excess syndrome in patients with chronic hepatitis B

更新时间：2022-08-31

- Comparative study on IL-1β level between deficiency and excess syndrome in patients with chronic hepatitis B
- Shanghai Journal of Traditional Chinese Medicine Vol. 52, Issue 9, Pages: 19-22(2018)
- 作者机构：
  
  1. 上海市奉贤区古华医院中医科,上海,201499
  2. 上海中医药大学附属龙华医院脾胃病二科,上海,200120
  3. 上海中医药大学脾胃病研究所,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2018.09.005
  CLC：
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SHEN Guohui, WANG Yuejiao, SONG Haiyan, et al. Comparative study on IL-1β level between deficiency and excess syndrome in patients with chronic hepatitis B. [J]. Shanghai Journal of Traditional Chinese Medicine 52(9):19-22(2018)
DOI：

SHEN Guohui, WANG Yuejiao, SONG Haiyan, et al. Comparative study on IL-1β level between deficiency and excess syndrome in patients with chronic hepatitis B. [J]. Shanghai Journal of Traditional Chinese Medicine 52(9):19-22(2018) DOI： 10.16305/j.1007-1334.2018.09.005.

摘要

目的：探究慢性乙型病毒性肝炎(慢乙肝)患者血清中白介素-1β(IL-1β)与虚、实证型之间的相关性,为慢乙肝中医辨证论治提供新的客观依据。方法：研究纳入慢乙肝患者156例,其中肝功能异常组120例、肝功能正常组36例,肝功能异常组根据临床表现再分为虚证组、实证组。入选病例均采集外周血血清,采用酶联免疫吸附法(ELISA法)检测外周血IL-1β表达水平,进而分析IL-1β水平与肝功能、虚实证型之间的相关性。结果：①肝功能异常组的血清IL-1β表达明显高于肝功能正常组(P<0.05)。②肝功能异常的慢乙肝患者中,虚证组中IL-1β的表达明显高于实证组(P<0.05)。结论：IL-1β或可成为慢乙肝患者虚实证型分类的客观指标及免疫治疗的新切入点。

Abstract

Objective:To investigate the correlation between serum IL-1β level and deficiency and excess syndrome in patients with chronic hepatitis B (CHB),and provide new objective basis for TCM syndrome differentiation and treatment on chronic hepatitis B. Methods156 patients with CHB were included,among which 120 cases in the abnormal liver function group and 36 cases in the normal liver function group. The abnormal liver function group was further divided into the deficiency syndrome group and excess syndrome group according to the clinical manifestations. The peripheral blood of patients was collected. The expression level of IL-1β in peripheral blood was detected by enzyme-linked immunosorbent assay (ELISA),and the correlation between IL-1β level and liver function,deficiency syndrome,excess syndrome was analyzed. Results:①The serum IL-1β expression level in the abnormal liver function group was obviously higher than that in the normal liver function group (P<0.05). ②Among the CHB patients with abnormal liver function,the IL-1β expression level in the deficiency syndrome group was obviously higher than that in the excess syndrome group (P<0.05). Conclusion:IL-1β may be an objective indicator for classification of deficiency and excess syndrome and a new pointcut for immunological therapy in CHB patients.

关键词

慢性乙型病毒性肝炎虚实证型IL-1β细胞免疫肝功能

Keywords

chronic hepatitis Bdeficiency and excess syndromeIL-1βcellular immunityliver function

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