Correlation between blood stasis syndrome and severity of coronary artery lesions and endothelial function in patients with coronary atherosclerosis

GUO Congcong; HUANG li; DONG Jianjun; FAN Zhengyuan; LIAO Lin

doi:10.16305/j.1007-1334.2018.09.004

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Correlation between blood stasis syndrome and severity of coronary artery lesions and endothelial function in patients with coronary atherosclerosis

更新时间：2022-08-31

- Correlation between blood stasis syndrome and severity of coronary artery lesions and endothelial function in patients with coronary atherosclerosis
- Shanghai Journal of Traditional Chinese Medicine Vol. 52, Issue 9, Pages: 15-18(2018)
- 作者机构：
  
  1. 山东中医药大学,山东,济南,250355
  2. 中日友好医院中西医结合心内科,北京,100029
  3. 山东大学齐鲁医院内分泌科,山东,济南,250014
  4. 山东省千佛山医院内分泌科,山东,济南,250014
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2018.09.004
  CLC：
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GUO Congcong, HUANG li, DONG Jianjun, et al. Correlation between blood stasis syndrome and severity of coronary artery lesions and endothelial function in patients with coronary atherosclerosis. [J]. Shanghai Journal of Traditional Chinese Medicine 52(9):15-18(2018)
DOI：

GUO Congcong, HUANG li, DONG Jianjun, et al. Correlation between blood stasis syndrome and severity of coronary artery lesions and endothelial function in patients with coronary atherosclerosis. [J]. Shanghai Journal of Traditional Chinese Medicine 52(9):15-18(2018) DOI： 10.16305/j.1007-1334.2018.09.004.

摘要

目的：探讨冠状动脉粥样硬化性心脏病血瘀证与冠脉病变程度及血管内皮功能的相关性。方法：纳入79例首次行冠状动脉造影检查并诊断为冠状动脉粥样硬化性心脏病的患者,根据造影结果行Gensini评分,并检查肱动脉内皮舒张功能(FMD)；记录中医证候与血瘀证积分,分析中医证素分布情况,以及血瘀证与FMD、Gensini评分的相关性。结果：冠状动脉粥样硬化性心脏病中医证素以血瘀最常见,血瘀证组FMD值低于非血瘀证组,Gensini评分高于非血瘀证组(P<0.05,P<0.01)。血瘀证积分与FMD值呈负相关(r=-0.597,P<0.01),与 Gensini评分呈正相关(r=0.693,P<0.01)；血瘀证积分与空腹血糖呈正相关(r=0.358,P<0.01),与糖化血红蛋白呈正相关(r=0.264,P<0.05),FMD与Gensini评分呈负相关(r=-0.700,P<0.01)。结论：冠状动脉粥样硬化性心脏病患者血瘀证越明显,其冠脉病变程度及内皮功能损伤越严重。

Abstract

Objective:To investigate the correlation between blood stasis syndrome and severity of coronary artery lesions and endothelial function in patients with coronary atherosclerosis. Methods79 patients who performed the first coronary angiography and diagnosed as coronary atherosclerosis were recruited. Gensini score was calculated according to the results of angiography,and the brachial artery endothelium-dependent vasodilation function was detected by flow-mediated dilatation (FMD). The scores of traditional Chinese medicine (TCM) syndrome and blood stasis syndrome were recorded. The distribution of TCM syndrome elements and the correlation between blood stasis syndrome and FMD and Gensini score were analyzed. Results:Among the TCM syndrome elements of patients with coronary atherosclerosis,blood stasis syndrome was the most common syndrome. The FMD value of patients with blood stasis syndrome was lower than that of patients without blood stasis syndrome,and the Gensini score was higher than that of patients without blood stasis syndrome (P<0.05,P<0.01). The blood stasis syndrome score was negatively correlated with FMD value (r=-0.597,P<0.01),and positively correlated with Gensini score (r=0.693,P<0.01). The blood stasis syndrome score was positively correlated with fasting blood glucose (r=0.358,P<0.01),and positively correlated with glycosylated hemoglobin (r=0.264,P<0.05). The FMD value was negatively correlated with Gensini score (r=-0.700,P<0.01). Conclusion:The more obvious the blood stasis syndrome is in patients with coronary atherosclerosis,the more serious the degree of coronary artery lesion and the damage of endothelial function are.

关键词

冠状动脉粥样硬化性心脏病肱动脉血管舒张功能内皮功能血瘀证Gensini评分

Keywords

coronary atherosclerosisbrachial artery vasodilation functionendothelial functionblood stasis syndromeGensini score

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