Effects of Zhu’s Bushen Huoxue Prescription on pregnancy outcome of patients with recurrent spontaneous abortion due to kidney deficiency and blood stasis combined with antiphospholipid syndrome

TAN Yuan; LI Guohua; ZHANG Qinhua

doi:10.16305/j.1007-1334.2018.08.018

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Effects of Zhu’s Bushen Huoxue Prescription on pregnancy outcome of patients with recurrent spontaneous abortion due to kidney deficiency and blood stasis combined with antiphospholipid syndrome

更新时间：2022-08-31

- Effects of Zhu’s Bushen Huoxue Prescription on pregnancy outcome of patients with recurrent spontaneous abortion due to kidney deficiency and blood stasis combined with antiphospholipid syndrome
- Shanghai Journal of Traditional Chinese Medicine Vol. 52, Issue 8, Pages: 61-64(2018)
- 作者机构：
  
  1. 同济大学附属第一妇婴保健院中西医结合科,上海,200040
  2. 同济大学附属第一妇婴保健院生殖免疫科,上海,200040
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2018.08.018
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TAN Yuan, LI Guohua, ZHANG Qinhua. Effects of Zhu’s Bushen Huoxue Prescription on pregnancy outcome of patients with recurrent spontaneous abortion due to kidney deficiency and blood stasis combined with antiphospholipid syndrome. [J]. Shanghai Journal of Traditional Chinese Medicine 52(8):61-64(2018)
DOI：

TAN Yuan, LI Guohua, ZHANG Qinhua. Effects of Zhu’s Bushen Huoxue Prescription on pregnancy outcome of patients with recurrent spontaneous abortion due to kidney deficiency and blood stasis combined with antiphospholipid syndrome. [J]. Shanghai Journal of Traditional Chinese Medicine 52(8):61-64(2018) DOI： 10.16305/j.1007-1334.2018.08.018.

摘要

目的：观察朱氏补肾活血方联合标准化西药治疗复发性流产合并抗磷脂综合征的临床疗效。方法：将98例肾虚血瘀型复发性流产合并抗磷脂综合征患者随机分为治疗组与对照组,每组49例。对照组予以标准化西药治疗方案,治疗组在对照组治疗措施基础上加服补肾活血方。观察妊娠结局(成功分娩、自然流产等),比较抗磷脂抗体(抗β2-GP1抗体)及凝血指标(D-二聚体、血小板聚集率)的变化情况。结果：①最终完成试验者,治疗组与对照组各40例。②随访得知,治疗组成功分娩36例、自然流产4例,对照组成功分娩29例、自然流产11例。组间活产率比较,治疗组明显高于对照组(P＜0.05)。③治疗前与妊娠12周组内比较,治疗组anti β2-GP1水平、血小板聚集率差异有统计学意义(P＜0.05),而D-D水平差异无统计学意义(P>0.05)；对照组anti β2-GP1水平差异有统计学意义(P＜0.05),而血小板聚集率、D-D水平差异无统计学意义(P>0.05)。组间治疗后比较,anti β2-GP1水平、血小板聚集率差异有统计学意义,治疗组明显低于对照组(P＜0.05)。结论：朱氏补肾活血方联合标准化西药治疗方案能明显提高复发性流产合并抗磷脂综合征患者的活产率,其机制可能与改善患者的凝血状态,调节相关免疫抗体有关。

Abstract

Objective:To observe the clinical efficacy of Zhu’s Bushen Huoxue Prescription combined with standard western medicine in the treatment of recurrent spontaneous abortion combined with antiphospholipid syndrome (APS-RSA). Methods98 patients with APS-RSA with Syndrome of kidney deficiency and blood stasis were randomly divided into the treatment group and control group, 49 cases in each group. The control group was treated with standard western medicine therapy, the treatment group was treated with Bushen Huoxue Prescription based on the treatment for the control group. The pregnancy outcome was observed, including successful delivery and spontaneous abortion. The changes on antiphospholipid antibody (anti β2-GP1 antibody) and coagulation indexes (D-Dimer and platelet aggregation rate) were compared. Results:①Finally 40 cases in the treatment group and 40 cases in the control group completed the trial. ②According to the follow-up, there were 36 cases of successfully delivery and 4 cases of spontaneous abortion in the treatment group, there were 29 cases of successfully delivery and 11 cases of spontaneous abortion in the control group. The live birth rate of the treatment group was obviously higher than that of the control group (P<0.05). ③Compared between treatment before and pregnancy for 12 weeks, there were statistically significant differences on the anti β2-GP1 level and platelet aggregation rate in the treatment group (P<0.05), while no statistically significant difference was observed on the D-D level (P>0.05); there was statistically significant difference on the anti β2-GP1 level in the control group (P<0.05), while no statistically significant differences were observed on the platelet aggregation rate and D-D level (P>0.05). After treatment, the anti β2-GP1 level and platelet aggregation rate in the treatment group were obviously lower than those in the control group, with statistically significant differences (P<0.05). Conclusion:Zhu’s Bushen Huoxue Prescription combined with standard western medicine therapy can obviously improve the live birth rate of patients with APS-RSA, its mechanism may be related to improving the blood coagulation and regulating the related immune antibodies.

关键词

抗磷脂综合征复发性流产补肾活血方朱南孙临床观察

Keywords

antiphospholipid syndromerecurrent spontaneous abortionBushen Huoxue PrescriptionZhu Nansunclinical observation

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