Objective:To discuss the clinical efficacy of Uric acid-reducing Decoction combined with allopurinol in the treatment of uric acid nephropathy with syndrome of qi deficiency of spleen and kidney and dampness-heat accumulated in interior. MethodsSixty patients of uric acid nephropathy with syndrome of qi deficiency of spleen and kidney and dampness-heat accumulated in interior were randomly divided into the treatment group and control group, 30 cases in each group. Both groups were orally treated with allopurinol tablets, and the treatment group was additionally treated with Uric acid-reducing Decoction, with a course of 28 days. The clinical efficacy was observed. The changes on uric acid, creatinine and urea nitrogen levels in serum, glomerular filtration rate, urinary β,2, microglobulin, N-acetyl-β-D glucosaminidase and 24 h urine protein quantity were compared.  Results:①The total effective rates were 80.0% in the treatment group and 50.0% in the control group, the clinical efficacy of the treatment group was better than that of the control group (P,<,0.05). ②Compared with treatment before, the levels of serum uric acid, serum creatinine, urinary β,2, microglobulin, N-acetyl-β-D glucosaminidase and 24 h urine protein quantity were decreased (P,<,0.05) and the glomerular filtration rate was obviously increased (P,<,0.05) in the treatment group, while only the serum level of uric acid was decreased in the control group (P,<,0.05) after treatment. There were statistically significant differences on above indexes between the two groups after treatment (P,<,0.05).  Conclusion:Uric acid-reducing Decoction combined with allopurinol in the treatment of uric acid nephropathy with syndrome of qi deficiency of spleen and kidney and dampness-heat accumulated in interior can not only significantly decrease the serum level of uric acid, but also improve the glomerular filtration function and renal tubule repair function, and reduce the proteinuria level.