Objective:To observe the clinical efficacy of Huayu Sanjie Enema in the treatment of adenomyosis with syndrome of blood stasis due to burning heat. Methods62 patients of adenomyosis with syndrome of blood stasis due to burning heat were randomly divided into the treatment group(32 cases)and control group(30 cases). The treatment group was treated with Huayu Sanjie Enema and the control group was treated with desogestrel and ethinylestradiol tablets,with a course of 3 menstrual cycles. The changes on the scores of dysmenorrhea,menstrual quantity and TCM syndrome,the uterine size and the level of serum carbohydrate antigen(CA)125 were observed and compared.  Results:①In both groups,there were statistically significant differences on the scores of dysmenorrhea,menstrual quantity and TCM syndrome between treatment before and after (P<0.05). After treatment,the TCM syndrome score in the treatment group was significantly lower than that in the control group (P<0.05),while there were no statistically significant differences on the scores of dysmenorrhea and menstrual quantity between the two groups(P>0.05). ②In both groups,there was statistically significant difference on the uterine size between treatment before and after (P<0.05). For the comparison between treatment before and after,there was statistically significant difference on the CA125 level in the treatment group (P<0.05),while there was no statistically significant difference in the control group(P>0.05). After treatment,the uterine size in the treatment group was obviously smaller than that in the control group (P<0.05),and the CA125 level in the treatment group was obviously lower than that in the control group (P<0.05).  Conclusion:Huayu Sanjie Enema shows satisfactory efficacy in the treatment of adenomyosis with syndrome of blood stasis due to burning heat,which can obviously relieve the clinical symptoms and signs of patients.