Objective:To observe the effects of Jingfang Baidu Powder on the protein and gene expressions of Nephrin, CD2-associated protein (CD2AP) and integrin linked kinase (ILK) in podocytes of adriamycin-induced nephropathy rat renal tissue. MethodsSD rats were randomly divided into the normal group, model group, benazepril group and Jingfang Baidu Powder group. Except the normal group, the rat model of nephropathy was established in other groups by single intravenous injection of adriamycin in tail. Each group was treated with the corresponding drug. The levels of 24 h urinary protein and renal function indexes in rats of each group were detected. The protein and gene expressions of Nephrin, CD2AP and ILK in the renal tissue were detected.  Results:Compared with the normal group, the levels of 24 h urinary protein and renal function indexes were obviously increased in the model group, the protein and gene expression levels of Nephrin and CD2AP were obviously down-regulated, whereas the protein and gene expression levels of ILK were significantly up-regulated in the model group. Compared with the model group, the levels of 24 h urinary protein and renal function indexes were obviously decreased in the Jingfang Baidu Powder group, the protein and gene expression levels of Nephrin and CD2AP were obviously up-regulated, whereas the protein and gene expression levels of ILK were significantly down-regulated in the Jingfang Baidu Powder group.  Conclusion:Jingfang Baidu Powder can decrease the proteinuria level in adriamycin-induced nephropathy rats. Its mechanism may be associated with the down-regulation of ILK expression and the up-regulation of Nephrin and CD2AP expressions in podocytes.