Ge Hong creates the unique thought of physique-spirit based on Lao-Zhuang’s thoughts. It is considered that physique takes spirit as the base,and spirit takes physique as the manifestation. The health preservation of physique-spirit emphasizes the noble morality,firm belief,harmony of body and mind,combination of dynamics and statics. Inspired by the thought of physique-spirit,the important contents of psychosomatic medicine should include carrying forward the concept of medical humanitarianism,deepening the thought of preventive treatment of disease and exploring its foundation of traditional culture.