This paper introduces Professor He Dongyi’s five methods in the treatment of rheumatoid arthritis. It is considered that rheumatoid arthritis is a syndrome of deficiency in origin and excess in superficiality. The treatment should focus on tonifying kidney to treat the root cause. The therapy of promoting blood circulation for removing blood stasis and dredging collateral for relieving rheumatism should be applied throughout the course of disease. Protecting spleen and stomach and preventing disease before disease onset are proposed. Meanwhile,taking internal and external treatment in combination is emphasized,the external or exercise therapies include Qin’s Xiaobi Ointment,joint health exercise and so on. The couplet medicines are made good use to eliminate pathogen. The pharmacological mechanism of Tripterygium wilfordii,a herb drug of anti-rheumatism with toxicity,is deeply explored.