Effects of catalpol on thyroid related indicators and cytokines in rats with hyperthyroidism

ZHANG Fan; LEI Yu; SHAO Yidan; GUO Feilong; XUAN Zhenyu

doi:10.16305/j.1007-1334.2018.04.023

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Effects of catalpol on thyroid related indicators and cytokines in rats with hyperthyroidism

更新时间：2022-08-31

- Effects of catalpol on thyroid related indicators and cytokines in rats with hyperthyroidism
- Shanghai Journal of Traditional Chinese Medicine Vol. 52, Issue 4, Pages: 81-85(2018)
- 作者机构：
  
  1. 上海中医药大学,上海,201203
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2018.04.023
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ZHANG Fan, LEI Yu, SHAO Yidan, et al. Effects of catalpol on thyroid related indicators and cytokines in rats with hyperthyroidism. [J]. Shanghai Journal of Traditional Chinese Medicine 52(4):81-85(2018)
DOI：

ZHANG Fan, LEI Yu, SHAO Yidan, et al. Effects of catalpol on thyroid related indicators and cytokines in rats with hyperthyroidism. [J]. Shanghai Journal of Traditional Chinese Medicine 52(4):81-85(2018) DOI： 10.16305/j.1007-1334.2018.04.023.

摘要

目的：研究梓醇对甲状腺功能亢进症大鼠的治疗作用。方法：通过皮下注射左旋甲状腺素钠(L-T4)诱导甲状腺功能亢进症模型,给药剂量为280 ng/g；将成模大鼠分为模型组,梓醇低(10 μg/g)、中(20 μg/g)、高(40 μg/g)剂量组,甲巯咪唑组(10 μg/g),丙硫氧嘧啶组(40 μg/g)。于给药21 d后检测各组大鼠的心率、心重指数、脾脏指数；酶联免疫法检测三碘甲状腺原氨酸(T3)、甲状腺素(T4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)和促甲状腺激素(TSH)、抗甲状腺微粒体抗体(TMAB)、甲状腺球蛋白抗体(TGAB)、肿瘤坏死因子(TNF-α)、白细胞介素6(IL-6)、白细胞介素2(IL-2)和白细胞介素10(IL-10)水平。结果：与模型组比较,梓醇中剂量组和梓醇高剂量组大鼠体质量差、心率,T3、T4、FT3、FT4、TGAB,IL-2/IL-10,全心、左心、脾脏指数等指标均明显降低(P<0.05),而TSH明显升高(P<0.05)。结论：梓醇具有一定的改善和治疗甲状腺功能亢进症的作用。

Abstract

Objective:To investigate the therapeutic effects of catalpol on hyperthyroidism in rats. MethodsThe hyperthyroid model was established by levothyroxine sodium (L-T4) with subcutaneous injection at dose of 280 ng/g. After successful modeling,the model rats were divided into the model group,thiamazole group (10 μg/g),propylthiouracil group (40 μg/g) and catalpol groups with low- (10 μg/g),middle-(20 μg/g) and high-(40 μg/g) dose. After treatment for 21 days,the heart rate,heart weight index and spleen index of rats in each group were measured. The levels of triiodothyronine (T3),thyroxine (T4),free triiodothyronine (FT3),free thyroxine (FT4),thyroid stimulating hormone (TSH),thyroid microsomal antibody (TMAB),thyroglobulin antibody (TGAB),tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6),interleukin-2 (IL-2) and interleukin-10 (IL-10) were detected by enzyme-linked immunosorbent assay . Results:Compared with the model group,the heart rate,the levels of T3,T4,FT3,FT4,TGAB,IL-2/IL-10,the index of whole heart,left heart and spleen were significantly decreased in the catalpol groups with middle- and high-dose (P<0.05),while the TSH level was increased significantly (P<0.05). Conclusion:Catalpol shows certain improving and therapeutic effects on hyperthyroidism.

关键词

梓醇甲状腺功能亢进症甲状腺激素水平治疗作用

Keywords

catalpolhyperthyroidismthyroid hormone leveltherapeutic effects

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