Influence oforal administration and external application of Chinese medicine on sex hormone levels and short-term pregnancy prognosis in patients of early threatened abortion with syndrome of kidney deficiency

MAO Yanwu; XU Sujun; XU Xiaomin; XU Tiantian; ZHENG Shanshan

doi:10.16305/j.1007-1334.2018.03.015

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Influence oforal administration and external application of Chinese medicine on sex hormone levels and short-term pregnancy prognosis in patients of early threatened abortion with syndrome of kidney deficiency

更新时间：2022-08-31

- Influence oforal administration and external application of Chinese medicine on sex hormone levels and short-term pregnancy prognosis in patients of early threatened abortion with syndrome of kidney deficiency
- Shanghai Journal of Traditional Chinese Medicine Vol. 52, Issue 3, Pages: 58-61(2018)
- 作者机构：
  
  1. 浙江省温州市中医院中医妇科,浙江,温州,325000
  2. 浙江省温州市中医院妇产科,浙江,温州,325000
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2018.03.015
  CLC：
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MAO Yanwu, XU Sujun, XU Xiaomin, et al. Influence oforal administration and external application of Chinese medicine on sex hormone levels and short-term pregnancy prognosis in patients of early threatened abortion with syndrome of kidney deficiency. [J]. Shanghai Journal of Traditional Chinese Medicine 52(3):58-61(2018)
DOI：

MAO Yanwu, XU Sujun, XU Xiaomin, et al. Influence oforal administration and external application of Chinese medicine on sex hormone levels and short-term pregnancy prognosis in patients of early threatened abortion with syndrome of kidney deficiency. [J]. Shanghai Journal of Traditional Chinese Medicine 52(3):58-61(2018) DOI： 10.16305/j.1007-1334.2018.03.015.

摘要

目的：观察中药内服(补肾安胎方)外敷(益肾保胎膏穴位贴敷)治疗肾虚型早期先兆流产的临床疗效。方法：将86例肾虚型早期先兆流产患者随机分为治疗组与对照组,每组43例。对照组予基础干预,肌肉注射黄体酮加益肾保胎膏穴位贴敷治疗,治疗组在对照组治疗措施基础上加服补肾安胎方。两组疗程均为2周、治疗后随访3个月,观察临床疗效、短期妊娠预后及用药安全性,比较中医证候积分及血清性激素水平,性激素包括血清孕酮(P)、雌二醇(E,2,)及人绒毛膜促性腺激素(HCG)。结果：①治疗组、对照组临床总有效率分别为97.7%、81.4%；组间临床疗效比较,治疗组明显优于对照组(P＜0.05)。②组间治疗后比较,中医证候积分差异有统计学意义,治疗组明显低于对照组(P＜0.05)。③组间治疗后比较,P、E,2,、HCG水平差异有统计学意义,治疗组明显高于对照组(P＜0.05)。④两组继续妊娠率(97.7% vs 83.7%)比较,差异有统计学意义,治疗组明显高于对照组(P＜0.05)。⑤两组不良反应发生率(4.7% vs 0%)比较,差异无统计学意义(P＞0.05)。结论：中药内服(补肾安胎方)外敷(益肾保胎膏穴位贴敷)治疗肾虚型早期先兆流产,可减轻患者临床症状,提高其血清性激素水平,改善妊娠预后,且安全性较好。

Abstract

Objective:To observe the clinical efficacy of Chinese medicine with oral administration (Bushen Antai Recipe) and acupoint application (Yishen Baotai Plaster) in the treatment of early threatened abortion with syndrome of kidney deficiency. Methods86 cases patients of early threatened abortion with syndrome of kidney deficiency were randomly divided into the control group and treatment group, 43 cases in each group. The control group was treated with intramuscular injection of progesterone and acupoint application of Yishen Baotai Plaster, the treatment group was treated with Bushen Antai Recipe based on the treatment for the control group. The two groups were treated for 2 weeks with follow-up for 3 months. The clinical efficacy, short-term pregnancy prognosis and medication safety were observed, and the TCM syndrome score and the levels of serum sex hormone were compared, including progesterone (P), estradiol (E,2,) and human chorionic gonadotropin (HCG). Results:①The clinical total effective rates were 97.7% in the treatment group and 81.4% in the control group. The clinical efficacy of the treatment group was significantly better than the control group (P,<,0.05). ②After the treatment, there was statistically significant difference on the TCM syndrome score between the two groups, and the score of the treatment group was significantly lower than that of the control group (P,<,0.05). ③After treatment, there were statistically significant differences on the levels of P, E2 and HCG between the two groups, and the levels in the treatment group were significantly higher than those in the control group (P,<,0.05). ④The continued pregnancy rates were 97.7% in the treatment group and 83.7% in the control group,with statistically significant difference,and the continued pregnancy rate of the treatment group was significantly higher than that of the control group (P,<,0.05). ⑤There was no statistically significant difference on the incidence rate of adverse reactions between the two groups (4.7% vs 0%) (P,>,0.05). Conclusion:Therapy of Chinese medicine with oral administration (Bushen Antai Recipe) and acupoint application (Yishen Baotai Plaster) in the treatment of early threatened abortion with syndrome of kidney deficiency can relieve the clinical symptoms of patients, improve the serum levels of sex hormone and pregnancy prognosis, with good safety.

关键词

早期先兆流产肾虚证内外合治性激素妊娠预后保胎安胎

Keywords

early threatened abortionkidney deficiency syndromecombined internal and external treatmentsex hormonepregnancy prognosistocolysis

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