Objective:To observe the clinical efficacy of Shen’s Shengdi Qinlian Tufuling Decoction in the treatment of Behcet’s disease. Methods68 patients with Behcet’s disease were randomly divided into the treatment group and control group,34 cases in each group. The treatment group was treated with Shen’s Shengdi Qinlian Tufuling Decoction(for continuous 2 months)combined with thalidomide tablets(25 mg/day for one month and then withdraw),the control group was treated with thalidomide tablets(50 mg/day in the first month and 25 mg/day in the second month). The treatment course was 2 months in both group, and the patients were followed-up until 4 months after the end of treatment. The clinical efficacy and adverse reactions were observed, the changes on the effective rate and recurrence rate of main symptoms, immune and acute inflammation indexes were compared.  Results:①The clinical total effective rates of the treatment group and control group were 94.1% and 85.3% respectively. The clinical efficacy of the treatment group was significantly better than that of the control group (P,<,0.05).②After treatment, there were statistically significant differences on the effective rates of mouth ulcer, ophthalmia and arthritis between the two groups (P ,<,0.05), while there were no statistically significant differences on the effective rates of the other main symptoms (P,>, 0.05). At the end of follow-up,there were statistically significant differences on the recurrence rates of mouth ulcer, erythema nodosum and arthritis between the two groups, and the recurrence rates of the treatment group were significantly lower than those of the control group (P,<,0.05). ③In both groups,there were statistically significant differences on the levels of ESR and CRP between treatment before and after (P,<,0.05), while there were no statistically significant differences on the levels of IgG and C,3, between treatment before and after (P,>, 0.05). After treatment,there were statistically significant differences on the levels of ESR and CRP between the two groups,and the levels in the treatment group were significantly lower than those in the control group (P,<,0.05).  Conclusion:Shen’s Shengdi Qinlian Tufuling Decoction in the treatment of Behcet’s disease can significantly improve the clinical symptoms, reduce the recurrence rate and adverse reactions on the basis of reducing the dosage and time of thalidomide.