This paper introduces Professor Wu Yaochi’s experience in treating multiple pain syndrome with qi-guiding acupuncture combined with substance-partitioned moxibustion,such as epigastric pain, headache, dysmenorrhea, back pain, facial pain, ophthalmodynia, pain of muscle and tendon injury, and arthromyodynia pain of neck, shoulder and knee. The clinical treatment should take acupuncture and moxibustion in combination,and emphasize the effective combination of acupoint massage and acupuncture.