Objective:To explore the effects of acupuncture combined with Shizhi Recipe on the uric acid(UA)and xanthine oxidase(XOD)activity in hyperuricemia rats with renal damage. Methods50 male SD rats of clean grade were selected and randomly divided into the normal group,model group,Chinese medicine(Shizhi Recipe)group,western medicine(allopurinol)group and acupuncture-drug(acupuncture plus Shizhi Recipe)group,10 rats in each group. The model was established by oteracil potassium at dose of 750 μg·g-1·d-1 by intragastric administration. After modeling,the treatments were performed in the everyday afternoon. The normal and model group were treated with distilled water at volume of 2 ml by intragastric administration,the Chinese medicine group was treated with Shizhi Recipe by intragastric administration,the western medicine group was treated with allopurinol by intragastric administration,and the acupuncture-drug group was treated with Shizhi Recipe and acupuncture. The acupuncture was performed at Pishu(B20),Shenshu(B23),Zusanli(S36)and Sanyinjiao(SP6)acupoints once every other day,and the retaining of needle was 30 minutes each time. After treatment for continuous 4 weeks,the levels of serum UA,serum creatinine(Scr),blood urea nitrogen(BUN),blood lipid indicators,24 h urinary UA,24 h urinary protein and XOD activities in the serum,liver and kidney of rats in each group were detected.  Results:Compared with the normal group,the levels of serum UA and 24 h urinary UA and the XOD activity were obviously increased in the model group,with statistically significant differences(P<0.05),but there were no statistically significant differences on the levels of BUN and Scr between the normal and model group(P<0.05),which suggested that the hyperuricemia model was successfully established. Compared with the model group,the serum UA level was significantly decreased and the total excretion of 24 h urinary UA was significantly increased and the XOD activities in the serum,liver and kidney were significantly decreased in the Chinese medicine group,western medicine group and acupuncture-drug group,with statistically significant differences(P<0.05),which suggested that all these treatments showed therapeutic effects. There were statistically significant differences on the levels of serum UA,24 h urinary UA,triacylglycerol and cholesterol and the XOD activities in the serum,liver and kidney between the Chinese medicine group and acupuncture-drug group(P<0.05),which suggested that the related efficacy of the acupuncture-drug group was better than that of the Chinese Medicine.  Conclusion:The combined acupuncture-drug therapy can effectively reduce the serum uric acid level and promote the urinary uric acid excretion in hyperuricemia rats with renal damage,improve the level of lipid metabolism and reduce the activities of XOD in serum,liver and kidney,which may be one of its mechanisms on the reduction of blood uric acid.