Effects of Jianpi Huayu Decoction on hemorheology and antioxidant activity in patients of senile macular degeneration with syndrome of deficiency of spleen qi

WU Xuezhi; YANG Yu; SHANG Yu

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Effects of Jianpi Huayu Decoction on hemorheology and antioxidant activity in patients of senile macular degeneration with syndrome of deficiency of spleen qi

更新时间：2022-08-31

- Effects of Jianpi Huayu Decoction on hemorheology and antioxidant activity in patients of senile macular degeneration with syndrome of deficiency of spleen qi
- Shanghai Journal of Traditional Chinese Medicine Vol. 52, Issue 1, Pages: 65-68(2018)
- 作者机构：
  
  1. 河南省驻马店市中心医院眼科,河南,驻马店,463000
  2. 黑龙江省佳木斯大学基础医学院,黑龙江,佳木斯,154007
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WU Xuezhi, YANG Yu, SHANG Yu. Effects of Jianpi Huayu Decoction on hemorheology and antioxidant activity in patients of senile macular degeneration with syndrome of deficiency of spleen qi. [J]. Shanghai Journal of Traditional Chinese Medicine 52(1):65-68(2018)
DOI：

WU Xuezhi, YANG Yu, SHANG Yu. Effects of Jianpi Huayu Decoction on hemorheology and antioxidant activity in patients of senile macular degeneration with syndrome of deficiency of spleen qi. [J]. Shanghai Journal of Traditional Chinese Medicine 52(1):65-68(2018) DOI：

摘要

目的：探讨健脾化瘀汤对老年性黄斑变性(SMD)患者血液流变学及抗氧化能力的影响。方法：将86例(114眼)SMD患者随机分为观察组和对照组,各43例(57眼)；对照组给予维生素E、维生素C、硫酸锌口服治疗,观察组给予健脾化瘀汤加减治疗,两组疗程均为3个月。观察两组治疗前后临床症状积分、视力改变、眼动脉血液流变学、血清丙二醛(MDA)与超氧化物歧化酶(SOD)等的变化。结果：①治疗后,两组临床症状积分均低于治疗前,视力、视敏度高于治疗前(P<0.05,P<0.01)；观察组临床症状积分低于对照组,视力、视敏度高于对照组(P<0.05,P<0.01)。②治疗后,两组眼动脉收缩期峰流速度(PSV)、舒张末期速度(EDV)均高于治疗前,阻力指数(RI)低于治疗前(P<0.05,P<0.01)；观察组PSV、EDV高于对照组,RI低于对照组(P<0.05,P<0.01)。③治疗后,两组血清MDA低于治疗前,SOD高于治疗前(P<0.05,P<0.01)；观察组MDA低于对照组,SOD高于对照组(P<0.05,P<0.01)。结论：健脾化瘀汤治疗SMD临床疗效良好,可改善眼部微循环和增强抗氧化能力。

Abstract

Objective:To discuss the effects of Jianpi Huayu Decoction on the hemorheology and antioxidant activity in patients with senile macular degeneration(SMD). Methods86 SMD patients(114 eyes)were randomly divided into the observation group and control group,43 cases(57 eyes)in each group. The control group was orally treated with vitamin E tablets,vitamin C tablets and zinc sulfate tablets,and the observation group was treated with modified Jianpi Huayu Decoction,with a course of 3 months. The changes on the clinical symptom score,vision,hemorheology of ophthalmic artery,serum levels of malondialdehyde(MDA)and superoxide dismutase(SOD)were observed in both groups before and after treatment. Results:①Compared with treatment before,the clinical symptom scores were decreased in both groups after treatment,and the vision and visual acuity were increased(P<0.05,P<0.01). After treatment,the clinical symptom score of the observation group was lower than that of the control group,and the vision and visual acuity in the observation group were higher than those in the control group(P<0.05,P<0.01). ②Compared with treatment before,the peak systolic velocity(PSV)and end diastolic velocity(EDV)of ophthalmic artery were increased in both groups after treatment,and the resistance index(RI)was decreased(P<0.05,P<0.01). After treatment,the levels of PSV and EDV in the observation group were higher than those in the control group,and the RI of the observation group was lower than that of the control group(P<0.05,P<0.01). ③Compared with treatment before,the serum MDA level was decreased and the SOD level was increased in both groups after treatment(P<0.05,P<0.01). After treatment,the MDA level in the observation group was lower than that in the control group,and the SOD level in the observation group was higher than that in the control group(P<0.05,P<0.01). Conclusion:Jianpi Huayu Decoction shows good clinical efficacy in the treatment of senile macular degeneration,which can improve the microcirculation in eyes and enhance the antioxidant activity.

关键词

老年性黄斑变性健脾化瘀汤血液流变学抗氧化能力

Keywords

senile macular degenerationJianpi Huayu DecoctionHemorheologyantioxidant activity

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