Effects of rutin on differentiation of 3T3-L1 preadipocytes

ZHANG Weiyun; WANG Qing; XIANG Yunya; WEN Zhongxiu; CHEN Quancheng

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Effects of rutin on differentiation of 3T3-L1 preadipocytes

更新时间：2022-08-31

- Effects of rutin on differentiation of 3T3-L1 preadipocytes
- Shanghai Journal of Traditional Chinese Medicine Vol. 52, Issue 1, Pages: 90-94(2018)
- 作者机构：
  
  1. 厦门医学院中心实验室,厦门市中药生物工程重点实验室,福建省中药精加工与健康产品开发重点研究室,福建省道地药材生物工程重点实验室,厦门医学院药学系,福建,厦门,361023
  2. 厦门大学药学院,福建,厦门,361102
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ZHANG Weiyun, WANG Qing, XIANG Yunya, et al. Effects of rutin on differentiation of 3T3-L1 preadipocytes. [J]. Shanghai Journal of Traditional Chinese Medicine 52(1):90-94(2018)
DOI：

ZHANG Weiyun, WANG Qing, XIANG Yunya, et al. Effects of rutin on differentiation of 3T3-L1 preadipocytes. [J]. Shanghai Journal of Traditional Chinese Medicine 52(1):90-94(2018) DOI：

摘要

目的：探索芦丁对3T3-L1 前脂肪细胞分化的影响。方法：采用3T3-L1 前脂肪细胞分化模型和油红O染色法,选用罗格列酮作为阳性对照药,观察芦丁对3T3-L1 前脂肪细胞分化的作用,于510 nm波长下测定芦丁对脂含量的影响。利用流式细胞仪测定芦丁对分化的脂肪细胞吸收葡萄糖的影响。结果：芦丁在0.5 μmol/L和1 μmol/L两个浓度下均能促进3T3-L1前脂肪细胞分化过程,提高脂含量,并促进了葡萄糖吸收。结论：芦丁能够促进3T3-L1前脂肪细胞分化,并促进了分化的脂肪细胞吸收葡萄糖。

Abstract

Objective:To investigate the influence of rutin on differentiation of 3T3-L1 preadipocytes. MethodsThe differentiation model of 3T3-L1 preadipocytes was established and oil red O staining was performed. Rosiglitazone was taken as the positive control drug. The effects of rutin on the differentiation of 3T3-L1 preadipocytes were observed,and the effect of rutin on the lipid content was detected at wavelength of 510 nm. The effects of rutin on the glucose absorption in differentiated adipocytes were determined by flow cytometry. Results:At the concentrations of 0.5 and 1 μmol/L,rutin could promote the differentiation of 3T3-L1 preadipocytes,increase the lipid content,and promote the glucose absorption. Conclusion:Rutin can promote the differentiation of 3T3-L1 preadipocytes and the glucose absorption in differentiated adipocytes.

关键词

芦丁3T3-L1前脂肪细胞分化糖吸收

Keywords

rutin3T3-L1 preadipocytesdifferentiationglucose absorption

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