Extraction process optimization of total flavonoids from Ziziphi Spinosae Fructus based on response surface methodology

MIAO Weiwei; YILIYAER Nijiati; YANG Tao; ZHOU Bin; Renaguli REYIMU; MUNIRE Aihemaiti; Ainiwaer AIKEMU

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Extraction process optimization of total flavonoids from Ziziphi Spinosae Fructus based on response surface methodology

更新时间：2022-08-31

- Extraction process optimization of total flavonoids from Ziziphi Spinosae Fructus based on response surface methodology
- Shanghai Journal of Traditional Chinese Medicine Vol. 52, Issue 1, Pages: 99-103(2018)
- 作者机构：
  
  1. 新疆医科大学药学院,新疆,乌鲁木齐,830011
  2. 新疆医科大学中心实验室,新疆,乌鲁木齐,830011
  3. 新疆医科大学维吾尔医学院,新疆,乌鲁木齐,830011
  4. 新疆医科大学基础医学院,新疆,乌鲁木齐,830011
- 作者简介：
- 基金信息：
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MIAO Weiwei, YILIYAER Nijiati, YANG Tao, et al. Extraction process optimization of total flavonoids from Ziziphi Spinosae Fructus based on response surface methodology. [J]. Shanghai Journal of Traditional Chinese Medicine 52(1):99-103(2018)
DOI：

MIAO Weiwei, YILIYAER Nijiati, YANG Tao, et al. Extraction process optimization of total flavonoids from Ziziphi Spinosae Fructus based on response surface methodology. [J]. Shanghai Journal of Traditional Chinese Medicine 52(1):99-103(2018) DOI：

摘要

目的：优化提取卡西卡甫枣总黄酮工艺条件。方法：选取料液比、提取温度和提取时间3个因素为考察指标,采用响应面法分析优化卡西卡甫枣总黄酮的提取工艺。结果：提取卡西卡甫枣总黄酮的最佳工艺条件为提取时间1.7 h、提取温度74 ℃、料液比1∶27,得到卡西卡甫枣总黄酮含量平均为1.403 mg/g,相对误差0.31%,与理论预测值较接近。结论：本法简便、可行,可为卡西卡甫枣总黄酮的高效提取以及后续工业生产提供参考。

Abstract

Objective:To optimize the extraction process of total flavonoids from Ziziphi Spinosae Fructus. MethodsTaken the solid-liquid ratio, ethanol concentration and extraction time as the indexes, the extraction process of total flavonoids from Ziziphi Spinosae Fructus was optimized by response surface methodology. Results:The optimum extraction conditions were as follows:The extraction time was 1.7 hours, the extraction temperature was 74 ℃, the solid-liquid ratio was 1∶27. The average content of total flavonoids was 1.403 mg/g, and the relative error was 0.31%, which was close to the theoretical prediction. Conclusion:This method is simple, convenient and feasible, which can provide references for the efficient extraction of total flavonoids from Ziziphi Spinosae Fructus as well as subsequent industrial production.

关键词

卡西卡甫枣总黄酮提取工艺响应面法

Keywords

Ziziphi Spinosae Fructustotal flavonoidsextraction processresponse surface methodology

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