Effects of traditional Chinese medicine on cAMP response element binding protein signaling pathway in cognitive impairment

DENG Haiyan; WANG Xiaowen; WANG Jian

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Effects of traditional Chinese medicine on cAMP response element binding protein signaling pathway in cognitive impairment

更新时间：2022-08-31

- Effects of traditional Chinese medicine on cAMP response element binding protein signaling pathway in cognitive impairment
- Shanghai Journal of Traditional Chinese Medicine Vol. 51, Issue 12, Pages: 95-98(2017)
- 作者机构：
  
  1. 上海中医药大学康复医学院,上海,201203
- 作者简介：
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DENG Haiyan, WANG Xiaowen, WANG Jian. Effects of traditional Chinese medicine on cAMP response element binding protein signaling pathway in cognitive impairment. [J]. Shanghai Journal of Traditional Chinese Medicine 51(12):95-98(2017)
DOI：

DENG Haiyan, WANG Xiaowen, WANG Jian. Effects of traditional Chinese medicine on cAMP response element binding protein signaling pathway in cognitive impairment. [J]. Shanghai Journal of Traditional Chinese Medicine 51(12):95-98(2017) DOI：

摘要

综述环磷酸腺苷应答元件结合蛋白(CREB)信号通路在中医药治疗认知障碍中的作用。CREB与神经元生成、突触可塑性及学习记忆等方面都有着紧密的联系,众多神经细胞内信号转导通路均能够交汇并参与诱导CREB的激活。CREB的磷酸化可受环磷酸腺苷信号通路、磷脂酰肌醇3 激酶/蛋白激B信号通路、p38丝裂原活化蛋白激酶通路及钙/钙调节蛋白依赖性蛋白激酶信号通路等多种信号转导通路的调节,这使得CREB信号通路及其相关分子成为认知障碍干预的药物靶点。

Abstract

This paper reviews the role of cAMP response element binding protein (CREB) signaling pathway in therapy of traditional Chinese medicine on cognitive impairment. CREB is closely related to neuronal generation,synaptic plasticity,learning and memory. Many signal transduction pathways within nerve cells can converge and involve in the induction of CREB activation. Multiple signal transduction pathways,such as cyclic adenosine monophosphate(cAMP)signaling pathway,phosphoinositide-3-kinase/ protein kinase B(PI3K/Akt)signaling pathway,p38 mitogen-activated protein kinase(p38MAPK)and calcium/ calmodulin-dependent protein kinaseⅡ(Ca,2+,-CAMKⅡ),can mediate the phosphorylation of CREB,which make the CREB signaling pathway and its related molecules become the drug targets in the treatment of cognitive impairment.

关键词

认知障碍CREB信号通路中医药疗法作用机制综述

Keywords

cognitive impairmentCREB signaling pathwaytherapy of traditional Chinese medicinemechanismreview

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