Objective:Based on the proven cases of primary immune thrombocytopenia that treated by Professor Huang zhenqiao,a national famous veteran practioner of traditional Chinese medicine,this study aimed to analyze the medication rules by data mining. Methods119 medical cases(involved 357 times visit)with definite diagnosis and relatively complete records were selected. After pretreatment,the standardized medical record database was established. Through software such as Microsoft Office Excel 2003,SPSS 18.0 and IBM SPSS Modeler 14.1,data mining were performed by frequency analysis,system cluster analysis and association analysis Apriori algorithm,respectively. From some aspects including commonly used Chinese materia medica,efficacy classification of Chinese materia medica,core drug groups,commonly used couplet medicines and drug and symptom correlation,Professor Huang Zhenqiao’s medication rules and characteristics in the treatment of primary immune thrombocytopenia were discussed.  Results:①A total of 217 kinds of Chinese materia medica were used. The commonly used drugs included Radix Astragali seu Hedysari,Radix Rehmanniae Recens,Rhizoma Atractylodis Macrocephalae,Radix Glycyrrhizae Preparata,Cortex Moutan Radicis,Radix Scutellariae,Radix Paeoniae Alba,Herba Taraxaci,Radix Rehmanniae Preparata,Poria,Pericarpium Citri Reticulatae,Radix Glycyrrhizae,Radix Codonopsis,Eclipta alba,Cortex Phellodendri,Cornu Bubali,Radix Angelicae Sinensis,Radix Rubiae,Radix Paeoniae Rubra,Radix Pseudostellariae,Rhizoma Coptidis,Caulis Perillae and Rhizoma Dioscoreae. The tonifying deficiency medicine,clearing heat medicine and blood-stanching medicine were commonly used Chinese materia medica. ②By systematic cluster analysis,six core drug groups were found. The 1st group included Radix Rehmanniae Recens,Cortex Moutan Radicis,Radix Scutellariae,Radix Paeoniae Alba,Radix Rehmanniae Preparata,Cortex Phellodendri and Cornu Bubali；the 2nd group included Rhizoma Atractylodis Macrocephalae,Radix Astragali seu Hedysari and Radix Glycyrrhizae Preparata；the 3rd group included Herba Taraxaci,Poria,Pericarpium Citri Reticulatae and Radix Glycyrrhizae；the 4th group included Radix Codonopsis and Radix Angelicae Sinensis；the 5th group included Eclipta alba,Radix Pseudostellariae and Caulis Perillae；the 6th group included Radix Rubiae,Radix Paeoniae Rubra,Rhizoma Coptidis and Rhizoma Dioscoreae. ③The association rule analysis showed that Professor Huang emphasized the compatibility of medicines in clinical practice,including yang-supplementing medicine with qi-supplementing,blood-supplementing,diuresis and diffusing dampness drugs,clearing heat and resolving phlegm medicine with relieving cough and asthma drugs and clearing heat and removing toxicity drugs,medicine for tranquillization with heavy prescription and suppressing hyperactive liver yang medicine with yin-supplementing drugs,qi-supplementing drugs and clearing heat and removing dampness drugs. Meanwhile some correlation rules of drug and symptom were summarized.  Conclusion:Professor Huang considers that the basic principles in the treatment of primary immune thrombocytopenia are purging fire to treat manifestation and suppressing liver-wood,treating both spleen and kidney to regulate yin and yang. The main treatment methods include clearing heat and cooling blood,benefiting qi for strengthening spleen,benefiting qi for nourishing blood,invigorating spleen for benefiting kidney,cooling blood for removing blood stasis and so on,and 6 kinds of commonly used drugs are summarized. Data mining can be used in the research on experience of famous veteran practioner of traditional Chinese medicine.