Clinical study of Modified Wuwei Xiaodu Decoction in the prevention and treatment of radiation pneumonia in patients with non-small cell lung cancer after chemotherapy

CHEN Si-qin; CHOU Tian-shu; WANG Ya-jing; HE Feng-jiao; YU Tian-jun; XIANG Ting-ting; ZHOU Jian

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Clinical study of Modified Wuwei Xiaodu Decoction in the prevention and treatment of radiation pneumonia in patients with non-small cell lung cancer after chemotherapy

更新时间：2022-08-31

- Clinical study of Modified Wuwei Xiaodu Decoction in the prevention and treatment of radiation pneumonia in patients with non-small cell lung cancer after chemotherapy
- Shanghai Journal of Traditional Chinese Medicine Vol. 51, Issue 11, Pages: 37-40(2017)
- 作者机构：
  
  1. 湖南省中医药研究院附属医院肿瘤科,湖南,长沙,410006
  2. 湖南中医药大学中西医结合学院,湖南,长沙,410208
- 作者简介：
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CHEN Si-qin, CHOU Tian-shu, WANG Ya-jing, et al. Clinical study of Modified Wuwei Xiaodu Decoction in the prevention and treatment of radiation pneumonia in patients with non-small cell lung cancer after chemotherapy. [J]. Shanghai Journal of Traditional Chinese Medicine 51(11):37-40(2017)
DOI：

CHEN Si-qin, CHOU Tian-shu, WANG Ya-jing, et al. Clinical study of Modified Wuwei Xiaodu Decoction in the prevention and treatment of radiation pneumonia in patients with non-small cell lung cancer after chemotherapy. [J]. Shanghai Journal of Traditional Chinese Medicine 51(11):37-40(2017) DOI：

摘要

目的：观察五味消毒饮加减方防治非小细胞肺癌患者放疗后放射性肺炎的临床疗效。方法：将120例非小细胞肺癌患者随机分为治疗组和对照组,每组60例。对照组予常规放疗、化疗,治疗组在放疗、化疗基础上加用五味消毒饮加减方。放疗及中药疗程均为1个月,观察两组放射性肺炎发生率及病情分级,比较身体机能状态评分(KPS)、肺损伤相关因子血清转化生长因子-β1(TGF-β1)的变化情况。结果：①两组完成试验病例共110例,其中治疗组55例、脱落5例,对照组55例、脱落5例,总脱落率为8.3%。②疗程结束后,治疗组、对照组的RP发生率分别为5.45%和20.00%,治疗组明显低于对照组(P<0.05)；两组病情分级比较,差异有统计学意义(P<0.05)。③组间治疗后比较,KPS评分差异有统计学意义,治疗组评分明显高于对照组(P<0.05)。④组间治疗后比较,TGF-β1水平差异有统计学意义,治疗组明显低于对照组(P<0.05)。结论：五味消毒饮加减方防治非小细胞肺癌患者放疗后放射性肺炎(RP),可明显减少RP的发生率,减轻急性放射性肺损害的程度(TGF-β1),改善患者的身体机能状态。

Abstract

Objective:To observe the clinical efficacy of Modified Wuwei Xiaodu Decoction in the prevention and treatment of radiation pneumonia(RP)in patients with non-small cell lung cancer after chemotherapy. Methods120 patients with non-small cell lung cancer were randomly divided into the treatment group and control group,60 cases in each group. The control group was treated with conventional radiotherapy and chemotherapy,and the treatment group was treated with Modified Wuwei Xiaodu Decoction based on the treatment for the control group. The treatment course of radiotherapy and Chinese medicine were both one month. The incidence of RP and disease condition grades in both groups were observed,and the changes on Karnofsky performance status(KPS)score and serum transforming growth factor-β1(TGF-β1)that related to lung injury were compared. Results:①A total of 110 cases completed the trial,among 55 cases in the treatment group and 55 cases in the control group(5 cases in each group fell off). The total expulsion rate was 8.3%. ②During the trial,the incidence rates of RP were 5.45% in the treatment group and 20.00% in the control group,the incidence rate of the treatment group was obviously lower than that of the control group(P<0.05). There was statistically significant difference on the disease condition grades between the two groups(P<0.05). ③After treatment,there was statistically significant difference on the KPS score between the two groups,and the score of the treatment group was obviously higher than that of the control group(P<0.05). ④After treatment,there was statistically significant difference on the TGF-β1 level between the two groups,and the level of the treatment group was obviously lower than that of the control group(P<0.05). Conclusion:Modified Wuwei Xiaodu Decoction can be used in the prevention and treatment of radiation pneumonia in patients with non-small cell lung cancer after chemotherapy,which can obviously reduce the incidence of RP,ease the degree of acute radiation lung injury and improve the patient’s physical status.

关键词

五味消毒饮非小细胞肺癌放射性肺炎治未病清热解毒益气养阴

Keywords

Modified Wuwei Xiaodu Decoctionnon-small cell lung cancerradiation pneumoniapreventive treatment of diseaseclearing heat and toxicitybenefiting qi and nourishing yin

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