This paper discusses the syndrome and treatment of distention and fullness due to depression syndrome.Distention and fullness due to depression syndrome mainly refers to gastric stuffiness and abdominal fullness triggered or aggravated by emotional factors.Its pathogenesis involve qi depression without pathogen,stagnation and visibility,and also can be food retention,phlegm stagnation,blood stasis or deficiency of qi and blood caused by stagnant qi movement. Apart from the spleen-stomach disorder,its clinical manifestations also can be accompanied by various symptoms. Its patterns include single depression syndrome and the coexistence of diseases and depression syndrome. It can be treated based on relieving depression or both on depression and diseases. The principles of treatment based on relieving depression include dispersing stagnated liver qi and regulating qi-flowing for eliminating stuffiness,activating spleen for eliminating dampness,dissipating phlegm and removing food stagnation. Identifying whether distention and fullness is induced by depression syndrome should refer to laboratory test.Distention and fullness due to depression syndrome is similar to functional dyspepsia,functional abdominal distention,aerophagia,irritable bowel syndrome,functional constipation or other functional gastrointestinal disorders correlated with psychological factors,or depression,anxiety,somatization disorder or other mental disorders.The theory and practice of distention and fullness due to depression syndrome in the diagnosis and treatment have got more and more support by modern medicine.