This paper introduces the thoughts and experience of Professor Liu Aihua in the treatment of diabetic nephropathy proteinuria. It is considered that the key to this disease are deficiency of spleen and kidney,dysfunction of spleen in ascending the clear and sinking of turbid toxin. And according to its etiology and pathogenesis,she puts forward the therapy principles of benefiting qi for strengthening kidney and ascending the clear and descending the turbid,and creates“Tangshen Shengqing Jiangzhuo Decoction”. The treatment of Chinese medicine according to disease and syndrome differentiation are flexibly applied,which could strengthen vital qi to eliminate pathogenic factor with deficiency and excess in combination and treat both manifestation and root cause of disease,and show good efficacy in clinic.