Efficacy observation of desloratadine citrate disodium combined with Yupingfeng Granule in the treatment of chronic urticaria

ZHAO Chun-hua; JIN Yi; QIAN Xiao-ying; ZHOU Yu

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Efficacy observation of desloratadine citrate disodium combined with Yupingfeng Granule in the treatment of chronic urticaria

更新时间：2022-08-31

- Efficacy observation of desloratadine citrate disodium combined with Yupingfeng Granule in the treatment of chronic urticaria
- Shanghai Journal of Traditional Chinese Medicine Vol. 51, Issue 9, Pages: 74-77(2017)
- 作者机构：
  
  1. 浙江省荣军医院皮肤科,浙江,嘉兴,314000
  2. 浙江省嘉兴市妇幼保健院皮肤科,浙江,嘉兴,314000
- 作者简介：
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ZHAO Chun-hua, JIN Yi, QIAN Xiao-ying, et al. Efficacy observation of desloratadine citrate disodium combined with Yupingfeng Granule in the treatment of chronic urticaria. [J]. Shanghai Journal of Traditional Chinese Medicine 51(9):74-77(2017)
DOI：

ZHAO Chun-hua, JIN Yi, QIAN Xiao-ying, et al. Efficacy observation of desloratadine citrate disodium combined with Yupingfeng Granule in the treatment of chronic urticaria. [J]. Shanghai Journal of Traditional Chinese Medicine 51(9):74-77(2017) DOI：

摘要

目的：观察枸地氯雷他定联合玉屏风颗粒治疗慢性荨麻疹(CU)临床效果。方法：将86例CU患者根据随机数字表法分为对照组和治疗组,每组43例。对照组予枸地氯雷他定口服,治疗组在此基础上予玉屏风颗粒口服,均治疗4周。观察临床疗效,荨麻疹活动度评分(UAS)评估病情严重程度,皮肤病生活质量指标评分(DLQI)评估生活质量,检测血清白介素-4(IL-4)、干扰素-γ(IFN-γ)、免疫球蛋白E(IgE)变化。结果：①对照组总有效率为72.09%,治疗组为90.70%；治疗组疗效明显优于对照组(P<0.05)。②治疗后,两组瘙痒、风团症状评分均降低(P<0.01),且治疗组低于对照组(P<0.01)。③治疗后,两组生活质量评分均显著降低(P<0.01),且治疗组低于对照组(P<0.01)。④治疗后,两组IL-4、IgE均降低(P<0.05),IFN-γ升高(P<0.05),且治疗组改善优于对照组(P<0.05)。结论：枸地氯雷他定联合玉屏风颗粒治疗慢性荨麻疹临床疗效确切,可提高患者生活质量、改善其免疫状态。

Abstract

Objective:To observe the clinical efficacy of desloratadine citrate disodium combined with Yupingfeng Granule in the treatment of chronic urticaria. Methods86 patients of chronic urticaria (CU) were divided into the control group and treatment group according to random number table,43 cases in each group. The control group was orally treated with desloratadine citrate disodium,and the treatment group was orally treated with Yupingfeng Granule based on the treatment for the control group,with a course of 4 weeks. The clinical efficacy was observed,the disease severity was evaluated by urticarial activity scale(UAS),the life quality was assessed by dermatology life quality index(DLQI),and the changes of serum interleukin-4(IL-4),interferon-γ(IFN-γ)and immunoglobulin E(IgE)were detected. Results:①The total effective rate was 72.09% in the control group and 90.70% in the treatment group. The clinical efficacy of the treatment group was obviously better than that of the control group(P<0.05). ②After treatment,the symptom scores of pruritus and wheal were decreased in both groups(P<0.01),and the scores of the treatment group were lower than those of the control group(P<0.01). ③After treatment,the DLQI was significantly decreased in both groups(P<0.01),and the DLQI of the treatment group was lower than that of the control group(P<0.01). ④After treatment,the levels of IL-4 and IgE were decreased and the IFN-γ level was increased in both groups(P<0.05),and the improvement in the treatment group was better than that in the control group(P<0.05). Conclusion:Desloratadine citrate disodium combined with Yupingfeng Granule shows definite clinical efficacy in the treatment of chronic urticaria,which can enhance the life quality and improve the immune state of patients.

关键词

荨麻疹枸地氯雷他定玉屏风颗粒IgE

Keywords

Urticariadesloratadine citrate disodiumYupingfeng GranuleIgE

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Department of Respiratory， Third Affiliated Hospital of Beijing University of Chinese Medicine

School of Traditional Chinese Medicine， Beijing University of Chinese Medicine

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Department of Pediatrics, Shanghai Municipal Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine

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