Professor Shi Qi considers the pathogenesis of musculoskeletal diseases as “disharmony of qi-blood in zang-fu viscera and imbalance between muscles and bones”,and emphasizes the therapeutic principle of “regulating the balance”in clinic,which refers to regulating the balance between muscles and bones to restore the solid skeleton and pliable tendons and promote the flow of qi-blood. He creates the clinical guiding principle of“qi and blood as basis,both Zang and Fu,muscles and bones in combination”,and establishes the theoretical and therapeutic research system of musculoskeletal diseases,and founds a series of prevention and treatment methods for degenerative musculoskeletal diseases,forms a series of manipulation and exercise of regulating the balance between muscles and bones. These treatments are widely used in the clinical rehabilitation of cervical spondylosis,adolescent idiopathic scoliosis and other diseases.