This paper discussed the syndrome and treatment of belching due to depression syndrome. Belching is not only the manifestation of spleen-stomach disease, but also the manifestation of liver disease, heart disease or other simple depression syndrome. Belching due to depression syndrome is induced by bad emotions, with characteristics of belching loudly, being controlled by self-consciousness and feeling comfortable after belching. Belching accompanied by other symptoms of spleen and stomach, mainly belongs to the coexistence of diseases and depression syndrome of liver-stomach disharmony, which needs to be treated on both diseases and depression. Belching accompanied by manifestation of liver qi stagnation or deficiency of heart-qi, mainly belongs to simple depression syndrome, which needs to be only treated on depression in clinic. Thus, the treatment of belching is far from promoting digestion and harmonizing stomach and descending adverse qi. The theory and practice of ancient Chinese medicine on the syndrome and therapy of belching due to depression syndrome have got more and more support from modern medicine.