Clinical research of Quyu Shengxin Formula combined with mesalazine in treating mild to moderate ulcerative colitis

GAN Dan; HAN Chang-peng; FENG Zhuo; JIN Wei; YANG Hao-jie; LI Ying; CUI Can; LIANG Rong-yu; WANG Yun-yun; WANG Zhen-yi

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Clinical research of Quyu Shengxin Formula combined with mesalazine in treating mild to moderate ulcerative colitis

更新时间：2022-08-31

- Clinical research of Quyu Shengxin Formula combined with mesalazine in treating mild to moderate ulcerative colitis
- Shanghai Journal of Traditional Chinese Medicine Vol. 51, Issue 8, Pages: 54-57(2017)
- 作者机构：
  
  1. 上海中医药大学附属岳阳中西医结合医院肛肠科,上海,200437
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GAN Dan, HAN Chang-peng, FENG Zhuo, et al. Clinical research of Quyu Shengxin Formula combined with mesalazine in treating mild to moderate ulcerative colitis. [J]. Shanghai Journal of Traditional Chinese Medicine 51(8):54-57(2017)
DOI：

GAN Dan, HAN Chang-peng, FENG Zhuo, et al. Clinical research of Quyu Shengxin Formula combined with mesalazine in treating mild to moderate ulcerative colitis. [J]. Shanghai Journal of Traditional Chinese Medicine 51(8):54-57(2017) DOI：

摘要

目的：观察祛瘀生新方联合美沙拉秦治疗轻中度溃疡性结肠炎(UC)的临床疗效。方法：将72例轻中度溃疡性结肠炎患者随机分为治疗组与对照组,每组36例。治疗组予祛瘀生新方联合美沙拉秦治疗,对照组仅予美沙拉秦治疗。两组疗程均为1个月,观察临床疗效,比较改良Mayo评分、UC生活质量评分及相关生化指标C反应蛋白(CRP)、红细胞沉降率(ESR)的变化情况。结果：①试验期间,治疗组脱落1例(因失访),最终完成试验者对照组36例、治疗组35例。②治疗组、对照组临床总有效率分别为88.57%、75.00%；组间临床疗效比较,治疗组明显优于对照组(P<0.05)。③治疗前后组内比较,两组改良Mayo评分差异均有统计学意义,均明显下降(P<0.05)。组间治疗前后差值比较,治疗组评分改变明显多于对照组(P<0.05)。④组间治疗后比较,UC生活质量评分(肠道症状、全身症状)差异有统计学意义,治疗组明显高于对照组(P<0.05)。⑤组间治疗后比较,CRP、ESR水平差异有统计学意义,治疗组明显低于对照组(P<0.05)。结论：祛瘀生新方联合美沙拉秦治疗轻中度溃疡性结肠炎,可明显改善活动期临床症状,抑制体内炎症反应,提高患者生活质量。

Abstract

Objective:To observe the clinical efficacy of Quyu Shengxin Formula combined with mesalazine in treating mild to moderate ulcerative colitis(UC). Methods 72 patients with mild to moderate ulcerative colitis were randomly divided into the treatment group and control group,36 cases in each group. The treatment group was treated with Quyu Shengxin Formula and mesalazine,and the control group was only treated with mesalazine,with a course of one month. The clinical efficacy was observed,and the changes of modified Mayo score,life quality scores of UC and the levels of related biochemical indexes including C reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were compared. Results: ①During the trial,one case in the treatment group fell off due to loss to follow-up,and finally 36 cases in the control group and 35 cases in the treatment group completed the trial.②The clinical total effective rate was 88.57% in the treatment group and 75.00% in the control group. The clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05). ③For the comparison between treatment before and after,there was statistically significant difference on the modified Mayo score in both groups,and the modified Mayo score was significantly decreased in both groups after treatment(P<0.05).For the comparison of the difference of treatment before and after,the difference of the modified Mayo score in the treatment was obviously greater than that in the control group(P<0.05).④For the comparison between the two groups after treatment,there were statistically significant differences on the life quality scores of UC(intestinal symptoms and systemic symptoms),the scores of the treatment group were obviously higher than those of the control group(P<0.05).⑤For the comparison between the two groups after treatment,there were statistically significant differences on the levels of CRP and ESR,the levels of the treatment group were obviously lower than those of the control group(P<0.05). Conclusion: Quyu Shengxin Formula combined with mesalazine can be used in the treatment of mild to moderate ulcerative colitis,which can significantly relieve the clinical symptoms in active stage,suppress the inflammatory reaction and improve the life quality of patients.

关键词

溃疡性结肠炎美沙拉秦祛瘀生新方补虚祛瘀生肌

Keywords

ulcerative colitismesalazineQuyu Shengxin Formulatonifying deficiency and removing blood stasis and promoting granulation

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