Study on quality control of Xuetong Capsule

HU Yi-hui; YUAN Shu-min; YANG Jun

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Study on quality control of Xuetong Capsule

更新时间：2022-08-31

- Study on quality control of Xuetong Capsule
- Shanghai Journal of Traditional Chinese Medicine Vol. 51, Issue 8, Pages: 98-102(2017)
- 作者机构：
  
  1. 上海中医药大学附属曙光医院GCP中心,上海,201203
  2. 上海中医药大学中药学院,上海,201203
  3. 上海市黄浦区香山中医医院药剂科,上海,200020
- 作者简介：
- 基金信息：
- DOI：
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HU Yi-hui, YUAN Shu-min, YANG Jun. Study on quality control of Xuetong Capsule. [J]. Shanghai Journal of Traditional Chinese Medicine 51(8):98-102(2017)
DOI：

HU Yi-hui, YUAN Shu-min, YANG Jun. Study on quality control of Xuetong Capsule. [J]. Shanghai Journal of Traditional Chinese Medicine 51(8):98-102(2017) DOI：

摘要

目的：建立完善的医院制剂质量标准以提高医院制剂血通胶囊的可控性和稳定性。方法：从定性、定量两方面进行研究,用薄层色谱法对血通胶囊中何首乌、水蛭、大黄三味中药定性鉴别；用高效液相色谱法对何首乌中二苯乙烯苷进行含量测定。结果：三味药材薄层色谱图斑点清晰,具有专属性；二苯乙烯苷标曲线性关系良好,精密度、重复性、稳定性和回收率实验结果较好。结论：该方法能准确可靠地进行定性、定量检测,能有效地控制血通胶囊的质量。

Abstract

Objective:To establish the perfect quality standard for hospital pharmaceutical preparation and improve the controllability and stability of Xuetong Capsule. Methods From the qualitative and quantitative analysis,the qualitative identification of three kinds of Chinese materia medica including Radix Polygoni Multiflori,Hirudo and Radix et Rhizoma Rhei in Xuetong Capsule was performed by thin-layer chromatography,and the content determination of tetrahydroxystilbene glucoside in Radix Polygoni Multiflori was performed by high performance liquid chromatography. Results: The three medicinal materials show the clear spots in thin layer chromatography with specificity. There is good linearity on the calibration curve of tetrahydroxystilbene glucoside,and the detection results of accuracy,repeatability,stability and recovery rate meet the requirement. Conclusion: The method is accurate and reliable for qualitative and quantitative detection,which can effectively control the quality of Xuetong Capsule.

关键词

血通胶囊质量标准薄层色谱法高效液相色谱法

Keywords

Xuetong Capsulequality standardthin-layer chromatographyhigh performance liquid chromatography

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Institute of Chinese Materia Medica， Shanghai University of Traditional Chinese Medicine， The MOE Key Laboratory for Standardization of Chinese Medicines， The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines， Shanghai R&D Center for Standardization of Chinese Medicines

Institute of Chinese Materia Medica，The MOE Key Laboratory for Standardization of Chinese Medicines and Shanghai Key Laboratory of Compound Chinese Medicine，Shanghai R&D Centre for Standardization of Chinese Medicine，Shanghai University of Traditional Chinese Medicine

Department of Pharmaceutical， Gongli Hospital， Shanghai Pudong New Area

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Key Laboratory of Standardization of Chinese Medicines， Ministry of Education， Institute of Chinese Materia Medica， Shanghai University of Traditional Chinese Medicine

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