Acid regurgitation due to depression syndrome refers to acid reflux caused by the seven emotions directly and indirectly,which presents two manifestations as single depression syndrome or the coexistence of diseases and depression syndrome.The coexistence of diseases and depression syndrome refers to liver-stomach diseases and incoordination between liver and stomach,mainly including the syndromes of liver qi invading stomach and stagnated heat in liver and stomach. The single depression syndrome refers to the corresponding syndromes caused by liver and heart (spleen) impairment due to seven emotions.Acid regurgitation of single depression syndrome induced by liver diseases may present with a few manifestations in liver meridian,or various complex physical symptoms involving multiple organs.The latter mainly belongs to recessive depression syndrome or generalized depression syndrome.The six stagnation diseases are also considered as the common pathogenesis of acid regurgitation due to depression syndrome. Acid regurgitation due to depression syndrome can be identified by its clinical features.The treatment should base on relieving depression or adjunctive therapy for depression. Acid regurgitation due to depression syndrome can be seen in the diseases such as gastroesophageal reflux and functional dyspepsia,depression,anxiety and somatoform disorders,which caused by mental and psychological factors in modern medicine.