Short term efficacy observation of Shidao Tongjie Granule combined with chemotherapy in the treatment of advanced esophageal cancer

CAI Xiao-yue; YANG Xi-wen; LU Wen-feng; JIN Chang-juan; ZHANG Ming; CUI Qing; LI Lei; GUO Yi-jun; DONG Yun; ZHOU Ya-ning

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Short term efficacy observation of Shidao Tongjie Granule combined with chemotherapy in the treatment of advanced esophageal cancer

更新时间：2022-08-31

- Short term efficacy observation of Shidao Tongjie Granule combined with chemotherapy in the treatment of advanced esophageal cancer
- Shanghai Journal of Traditional Chinese Medicine Vol. 51, Issue 7, Pages: 44-47(2017)
- 作者机构：
  
  1. 上海交通大学附属胸科医院中西医结合科,上海,200030
  2. 上海交通大学医学院研究生院,上海,200025
- 作者简介：
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CAI Xiao-yue, YANG Xi-wen, LU Wen-feng, et al. Short term efficacy observation of Shidao Tongjie Granule combined with chemotherapy in the treatment of advanced esophageal cancer. [J]. Shanghai Journal of Traditional Chinese Medicine 51(7):44-47(2017)
DOI：

CAI Xiao-yue, YANG Xi-wen, LU Wen-feng, et al. Short term efficacy observation of Shidao Tongjie Granule combined with chemotherapy in the treatment of advanced esophageal cancer. [J]. Shanghai Journal of Traditional Chinese Medicine 51(7):44-47(2017) DOI：

摘要

目的：观察食道通结颗粒联合化疗治疗中晚期食管癌的近期临床疗效。方法：将80例中晚期食管癌患者随机分为治疗组和对照组,每组40例。对照组予紫杉醇加卡铂的方案化疗,治疗组在对照组治疗措施基础上加用食道通结颗粒。两组疗程均为2个月,观察近期疗效,比较中医证候积分、化疗不良反应及免疫功能指标的变化情况。结果：①治疗组、对照组临床总有效率分别为55.00%、32.50%；组间近期疗效比较,治疗组明显优于对照组(P,<,0.05)。②组间治疗后中医证候积分比较,差异有统计学意义,治疗组中医证候积分明显低于对照组(P,<,0.05)。③试验期间,组间化疗不良反应(白细胞、血小板减少,贫血,恶心呕吐)比较,治疗组反应程度明显低于对照组(P,<,0.05)。④组间治疗后比较,CD3,+,、CD4,+,、CD8,+, 、CD4,+,/CD8,+,及NK细胞水平差异有统计学意义(P,<,0.05)。结论：食道通结颗粒可显著提高中晚期食管癌的近期疗效,改善临床症状,减轻化疗后不良反应,同时调节患者的免疫功能。

Abstract

Objective:To observe the short term clinical efficacy of Shidao Tongjie Granule combined with chemotherapy in the treatment of advanced esophageal cancer. Methods80 patients with advanced esophageal cancer were randomly divided into the control group and treatment group, 40 cases in each group. The control group was treated with chemotherapy of paclitaxel and carboplatin,the treatment group was additionally treated with Shidao Tongjie Granule based on the treatment for the control group,with a course of 2 months. The short term efficacy was observed,and the changes of Chinese medical syndrome score,adverse reactions induced by chemotherapy and immune function indexes were compared. Results:①The clinical total effective rate was 55.00% in the treatment group and 32.50% in the control group. The short term efficacy in the treatment group was significantly better than that in the control group(P,<,0.05). ②There was statistically significant difference on the Chinese medical syndrome score between the two groups after treatment,and the Chinese medical syndrome score of the treatment group was significantly lower than that of the control group(P,<,0.05). ③During the treatment,the adverse reactions induced by chemotherapy including aleucocytosis,thrombocytopenia,anemia and pernicious vomiting were significantly improved in the treatment group compared with the control group(P,<,0.05). ④There were statistically significant differences on the levels of CD3,+,CD4,+,CD8,+,CD4,+,/CD8,+and, NK cells between the two groups after treatment(P,<,0.05). Conclusion:Shidao Tongjie Granule can significantly enhance the short term efficacy in the treatment of advanced esophageal cancer,which improve the clinical symptoms,alleviate the adverse reactions induced by chemotherapy and regulate the immune function of patients.

关键词

食管癌中晚期食道通结颗粒化疗中西医结合减毒增效

Keywords

esophageal canceradvanced stageShidao Tongjie Granulechemotherapyintegrated Chinese and western medicinereducing toxicity and enhancing efficacy

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