Effects of Taohong Siwu Decoction on bone metabolism in patients with fracture of tibial plateau after fixation operation

FU Ai-ling

您当前的位置：

首页 >

文章列表页 >

Effects of Taohong Siwu Decoction on bone metabolism in patients with fracture of tibial plateau after fixation operation

更新时间：2022-08-31

- Effects of Taohong Siwu Decoction on bone metabolism in patients with fracture of tibial plateau after fixation operation
- Shanghai Journal of Traditional Chinese Medicine Vol. 51, Issue 7, Pages: 57-59(2017)
- 作者机构：
  
  1. 河南省郑州市骨科医院疼痛科,河南,郑州,450052
- 作者简介：
- 基金信息：
- DOI：
  CLC：
扫描看全文
FU Ai-ling. Effects of Taohong Siwu Decoction on bone metabolism in patients with fracture of tibial plateau after fixation operation. [J]. Shanghai Journal of Traditional Chinese Medicine 51(7):57-59(2017)
DOI：

FU Ai-ling. Effects of Taohong Siwu Decoction on bone metabolism in patients with fracture of tibial plateau after fixation operation. [J]. Shanghai Journal of Traditional Chinese Medicine 51(7):57-59(2017) DOI：

摘要

目的：研究桃红四物汤对胫骨平台骨折固定术后患者骨代谢的影响。方法：将76例胫骨平台骨折患者随机分为对照组和观察组(各38例),并均行内外双钢板固定治疗；观察组同时加用桃红四物汤治疗,治疗2个疗程。观察两组临床疗效及治疗前后骨代谢指标变化情况。结果：观察组临床总有效率为97.37%,对照组为81.59%；观察组的临床疗效优于对照组(P<0.05)。治疗后两组骨形成指标血清ALP、IGF-Ⅰ、PINP和骨代谢指标血清MMP-1、MMP-2、sCTx表达水平均高于治疗前(P<0.05),且观察组均高于对照组(P<0.05)。结论：桃红四物汤能够显著改善胫骨平台骨折固定术后患者膝关节功能和骨代谢以促进骨折愈合。

Abstract

Objective:To study the effects of Taohong Siwu Decoction on bone metabolism in patients with fracture of tibial plateau after fixation operation. Methods76 patients with fracture of tibial plateau were randomly divided into the control group and treatment group,38 cases in each group. All the patients were treated with internal and external double plate fixation. Meanwhile,the patients in the treatment group were treated with Taohong Siwu Decoction in addition,with a course of 28 days. The clinical efficacy was observed in both groups,and the changes of bone metabolism indexes were compared before and after treatment. Results:The clinical total effective rate was 97.37% in the treatment group and 81.59% in the control group. The clinical efficacy of the treatment group was better than that of the control group(P<0.05).Compare with treatment before,the serum levels of bone formation indexes including alkaline phosphatase (ALP),insulin-like growth factor I (IGF-I) and procollagen type I N-terminal propeptide (PINP) and the serum levels of bone metabolism indexes including matrix metalloproteinase-1 (MMP-1),matrix metalloproteinase-2 (MMP-2) and collagen type I cross-linked C-terminal peptide (sCTx) were increased in both groups after treatment (P<0.05),and the levels in the treatment group were all higher than those in the control group(P<0.05). Conclusion:Taohong Siwu Decoction can significantly improve the knee joint function and bone metabolism in patients with fracture of tibial plateau after fixation operation,which promote the fracture healing.

关键词

胫骨平台骨折桃红四物汤固定术骨代谢

Keywords

fracture of tibial plateauTaohong Siwu Decoctionfixation operationbone metabolism

references

Views

下载量

CSCD

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

A randomized， double‑blind， placebo‑controlled clinical trial on the external application of Taohong Siwu Decoction to improve the arteriovenous fistula patency during hemodialysis

Clinical study on treatment of severe non‑proliferative diabetic retinopathy with modified Taohong Siwu Decoction and laser therapy

Research progress of modified Taohong Siwu Decoction in treatment of femoral head necrosis

Clinical study on five animal exercises combined with calcium in the treatment of primary osteoporosis

Clinical observation of effects of Taohong Siwu Decoction on bone mineralization in the process of bone transport

Related Author

No data

Related Institution

Department of Nephrology， Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine

Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Affiliated Hospital of Qingdao Binhai University

Graduate School of Hunan University of Traditional Chinese Medicine

Hip Injury Department of Luoyang Orthopedic Hospital of Henan Province /Orthopedic Hospital of Henan Province

⁰