Clinical study of Zizhu Ointment with external application in the treatment of venous ulcer in lower limb

YANG Xiao; LIU Guo-bin; ZHANG Lei; YAN Shao-qing; WANG Li-xiang

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Clinical study of Zizhu Ointment with external application in the treatment of venous ulcer in lower limb

更新时间：2022-08-31

- Clinical study of Zizhu Ointment with external application in the treatment of venous ulcer in lower limb
- Shanghai Journal of Traditional Chinese Medicine Vol. 51, Issue 7, Pages: 60-62(2017)
- 作者机构：
  
  1. 上海中医药大学附属曙光医院外七科,上海,201203
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YANG Xiao, LIU Guo-bin, ZHANG Lei, et al. Clinical study of Zizhu Ointment with external application in the treatment of venous ulcer in lower limb. [J]. Shanghai Journal of Traditional Chinese Medicine 51(7):60-62(2017)
DOI：

YANG Xiao, LIU Guo-bin, ZHANG Lei, et al. Clinical study of Zizhu Ointment with external application in the treatment of venous ulcer in lower limb. [J]. Shanghai Journal of Traditional Chinese Medicine 51(7):60-62(2017) DOI：

摘要

目的：观察紫朱软膏外敷治疗下肢静脉性溃疡的临床疗效。方法：将60例下肢静脉性溃疡患者随机分为治疗组和对照组,每组30例。治疗组予紫朱软膏外敷治疗,对照组予重组牛碱性成纤维细胞生长因子(贝复济)喷剂联合乳酸依沙吖啶溶液湿敷换药治疗。两组疗程均为100天,观察临床疗效,比较溃疡的面积与最大直径,以及溃疡愈合时间的情况。结果：①治疗组、对照组临床总有效率分别为96.67%和83.33%；组间临床疗效比较,治疗组显著优于对照组(P<0.05)。②组间治疗后比较,治疗组溃疡面积及最大直径缩小、缩短较对照组更加明显(P<0.05)。③试验期间,两组痊愈患者的溃疡愈合时间比较,治疗组明显短于对照组(P<0.05)。结论：紫朱软膏外敷治疗下肢静脉性溃疡,能显著改善疮面环境,提高治愈率,缩短病程。

Abstract

Objective:To observe the clinical efficacy of Zizhu Ointment with external application in the treatment of venous ulcer in lower limb. Methods60 patients of venous ulcer in lower limb were randomly divided into the treatment group and control group,30 cases in each group. The treatment group was treated with Zizhu Ointment for external application,and the control group was treated with spray of recombinant bovine basic fibroblast growth factor and ethacridine lactate solution for moisten compress,with a course of 100 days. The clinical efficacy was observed,and the ulcer area,the maximum diameter and the healing time were compared. Results:①The clinical total effective rate of the treatment group and the control group were 96.67% and 83.33% respectively,and the clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05).②For the comparison between the two groups after treatment,the decrease of ulcer area and maximum diameter in the treatment group were more significant than those in the control group(P<0.05). ③During the trial,the healing time of ulcer in the treatment group was significantly shorter than that in the control group(P<0.05). Conclusion:Zizhu Ointment with external application can be used in the treatment of venous ulcer in lower limb,which significantly improve the wound environment,enhance the cure rate and shorten the course of disease.

关键词

下肢静脉性溃疡臁疮紫朱软膏溃疡面积愈合时间奚九一

Keywords

venous ulcer in lower limbecthymaZizhu Ointmentulcer areahealing timeXi Jiuyi

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