From the therapy of eliminating pathogenic factors in the treatment of exogenous diseases,this paper analyzed the prescription significance and efficacy characteristics of Shengjiang Powder,explicated its application and the related pathogenesis. It reflects that the therapy idea of eliminating pathogenic factors from multi orifices is the application model of “exogenous pathogenic factors invading into and dispelling out from orifices”. It emphasizes the rising and falling of qi movement and takes clearing heat as main with cold and warm in combination, and forms the compatibility characteristics of interaction.