Objective:To discuss the effects of Shengqing Capsule on abnormal lipid metabolism and breast cancer with liver metastasis by CXCL12-CXCR4 signaling pathway. Methods(1) Human breast cancer cells line MDA-MB-231 was selected and divided into the control group, blank serum group, Epirubicin group and Shengqing Capsule groups with high-and low-concentration. Each group was treated with the corresponding drug contained serum. The effect of drug contained serum on cell proliferation was detected by MTT assay,the effects of drug contained serum on cell migration and invasion were detected by scratch test and Transwell assay. The protein expressions of chemokine ligand CXCL12 and its specific receptor CXCR4 and phosphorylated protein kinase B(p-AKT), protein kinase B(AKT), B-cell leukemia lymphoma-2(Bcl-2)and matrix metallopeptidase-9(MMP-9)were detected by Western blotting. (2) Nude mouse model of breast cancer with liver metastasis and abnormal lipid metabolism was established. The Shengqing Capsule at dose of 0.25 g·kg-1 and Epirubicin at dose of 5 μg·g-1 were given for intervention. The level changes of free fatty acid (FFA) and triglyceride (TG) in plasma were detected,and the effects of Shengqing Capsule on breast cancer with liver metastasis were evaluated.  Results:(1) The MTT assay showed that drug contained serum of Shengqing Capsule and Epirubicin could significantly decrease the survival rate of MDA-MB-231 cells in a concentration-dependent manner(P<0.05). The scratch test and Transwell assay showed that drug contained serum of Shengqing Capsule could significantly inhibit the cell invasion and migration. The results of Western blotting showed that drug contained serum of Shengqing Capsule could decrease the protein expressions of CXCL12 and CXCR4 compared with the control group(P<0.05),and down-regulate the protein expressions of MMP-9 and Bcl-2 and reduce the p-AKT level(P<0.05).(2)The results of animal experiment showed that Shengqing Capsule could significantly decrease the levels of TG and FFA in nude mice with abnormal lipid metabolism(P<0.05),and inhibit the liver metastasis of breast cancer.  Conclusion:Shengqing Capsule can down-regulate the blood lipid levels and suppress the liver metastasis of breast cancer by inhibiting the expressions of CXCL12,CXCR4 and the related signaling pathway.