Effects of Compound Fo’ercao Mixture on inflammatory factors in peripheral blood and expression of Toll like receptors in monocytes of AECOPD patients:A randomized, double-blind, placebo-controlled study

ZHE Zhe; LI Feng-sen; ZHAO Zhi-xiang; LIU Dan; XIONG Bi-dan; CHENG Ya-nan; SHI Ke-hua

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Effects of Compound Fo’ercao Mixture on inflammatory factors in peripheral blood and expression of Toll like receptors in monocytes of AECOPD patients:A randomized, double-blind, placebo-controlled study

更新时间：2022-08-31

- Effects of Compound Fo’ercao Mixture on inflammatory factors in peripheral blood and expression of Toll like receptors in monocytes of AECOPD patients:A randomized, double-blind, placebo-controlled study
- Shanghai Journal of Traditional Chinese Medicine Vol. 51, Issue 6, Pages: 38-41(2017)
- 作者机构：
  
  1. 上海中医药大学附属市中医医院呼吸科,上海,200071
  2. 新疆维吾尔自治区中医医院呼吸科,新疆,乌鲁木齐,830000
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ZHE Zhe, LI Feng-sen, ZHAO Zhi-xiang, et al. Effects of Compound Fo’ercao Mixture on inflammatory factors in peripheral blood and expression of Toll like receptors in monocytes of AECOPD patients:A randomized, double-blind, placebo-controlled study. [J]. Shanghai Journal of Traditional Chinese Medicine 51(6):38-41(2017)
DOI：

ZHE Zhe, LI Feng-sen, ZHAO Zhi-xiang, et al. Effects of Compound Fo’ercao Mixture on inflammatory factors in peripheral blood and expression of Toll like receptors in monocytes of AECOPD patients:A randomized, double-blind, placebo-controlled study. [J]. Shanghai Journal of Traditional Chinese Medicine 51(6):38-41(2017) DOI：

摘要

目的：观察复方佛耳草合剂对慢性阻塞性肺疾病急性加重(AECOPD)患者血清IL-8、TNF-α水平及外周血单核细胞Toll样受体(TLR2、TLR4)表达的影响。方法：将120例AECOPD患者随机分为治疗组和对照组,每组60例。在常规西药治疗基础上,治疗组加服复方佛耳草合剂,对照组加服复方佛耳草合剂安慰剂。两组疗程均为14天,观察比较中医证候积分、血清炎症因子及外周血单核细胞Toll样受体(TLRs)水平的变化情况。结果：①最终完成试验者107例,治疗组51例,对照组56例。②组间治疗后比较,治疗组咳嗽、咯痰评分及总积分较对照组下降更加明显(P<0.05)。③组间治疗后比较,治疗组IL-8水平较对照组下降更加明显(P<0.05)。④组间治疗后比较,治疗组TLR2、TLR4水平较对照组升高更加明显(P<0.05)。⑤治疗前后血清炎症因子IL-8、TNF-α水平与外周血单核细胞TLR2、TLR4表达水平均具有良好的负相关性。⑥所有患者均未出现常规检查异常及严重不良反应。结论：复方佛耳草合剂联合常规西药治疗AECOPD,可显著改善患者咳嗽、咯痰症状,可能与其减轻气道炎症反应、增强机体固有免疫应答有关。

Abstract

Objective:To observe the effects of Compound Fo’ercao Mixture on the serum levels of inflammatory factors(IL-8,TNF-α) and expressions of Toll like receptors(TLRs) in peripheral blood mononuclear cells of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods 120 patients with AECOPD were randomly divided into the treatment group and control group,60 cases in each group. Both groups were given the conventional therapy of western medicine. In addition,the treatment group was treated with Compound Fo’ercao Mixture,and the control group was treated with the placebo,with a course of 14 days. The changes of TCM syndrome scores,serum levels of IL-8,TNF-α and expressions of TLR2,TLR4 in peripheral blood mononuclear cells were observed and compared. Results: ①Finally 107 cases completed the whole trial,among 51 cases in the treatment group and 56 cases in the control group. ②After treatment,the decrease of the scores on cough,expectoration and the total score in the treatment group were more significant than those in the control group(P<0.05). ③After treatment,the decrease of IL-8 level in the treatment group was more significant than that in the control group(P<0.05). ④After treatment,the increase of the expression levels of TLR2 and TLR4 in the treatment group were more significant than those in the control group(P<0.05). ⑤There were good negative correlations between the serum levels of IL-8,TNF-α and expression levels of TLR2 and TLR4 in peripheral blood mononuclear cells before and after treatment. ⑥All patients had no abnormality in routine inspection and severe adverse reactions. Conclusion: Compound Fo’ercao Mixture combined with conventional therapy of western medicine can significantly improve the main symptoms such as cough and expectoration in AECOPD patients,which may be associated with alleviating the airway inflammation and enhancing the innate immune response.

关键词

慢性阻塞性肺疾病急性加重期复方佛耳草合剂炎症反应免疫应答

Keywords

chronic obstructive pulmonary diseaseacute exacerbationCompound Fo’ercao Mixtureinflammatory reactionimmune response

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