Clinical research of Modified Weichang’an Decoction combined with chemotherapy in treating elderly patients with stage Ⅳ colorectal cancer

ZHU Ying-jie; MENG Dan; WANG Hao; XU Yi; ZHENG Jian; TAO Li; GU Ying

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Clinical research of Modified Weichang’an Decoction combined with chemotherapy in treating elderly patients with stage Ⅳ colorectal cancer

更新时间：2022-08-31

- Clinical research of Modified Weichang’an Decoction combined with chemotherapy in treating elderly patients with stage Ⅳ colorectal cancer
- Shanghai Journal of Traditional Chinese Medicine Vol. 51, Issue 6, Pages: 46-48(2017)
- 作者机构：
  
  1. 上海中医药大学附属龙华医院肿瘤科,上海,200032
  2. 河北省中医院肿瘤一科,河北,石家庄,050011
- 作者简介：
- 基金信息：
- DOI：
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ZHU Ying-jie, MENG Dan, WANG Hao, et al. Clinical research of Modified Weichang’an Decoction combined with chemotherapy in treating elderly patients with stage Ⅳ colorectal cancer. [J]. Shanghai Journal of Traditional Chinese Medicine 51(6):46-48(2017)
DOI：

ZHU Ying-jie, MENG Dan, WANG Hao, et al. Clinical research of Modified Weichang’an Decoction combined with chemotherapy in treating elderly patients with stage Ⅳ colorectal cancer. [J]. Shanghai Journal of Traditional Chinese Medicine 51(6):46-48(2017) DOI：

摘要

目的：观察胃肠安方加减联合以5-氟尿嘧啶为基础的化疗方案治疗Ⅳ期老年结直肠癌的临床疗效。方法：将133例Ⅳ期老年结直肠癌患者分为治疗组(68例)和对照组(65例),两组患者均以5-氟尿嘧啶为基础方案化疗3个疗程,治疗组同时采用胃肠安方加减口服。比较两组近期疗效、毒副反应、生活质量及总生存期情况。结果：①近期疗效中,两组总有效率和疾病控制率无统计学差异(P>0.05)；②治疗组患者生活质量优于对照组(P<0.01)；③治疗组中位PFS和中位OS均比对照组显著延长(P<0.05)；④治疗组白细胞减少和末梢神经毒性等毒副反应均低于对照组(P<0.05,P<0.01)。结论：胃肠安方加减联合以5-氟尿嘧啶为基础的化疗方案治疗Ⅳ期老年结直肠癌,可提高患者近期疗效,减少毒副反应,改善生活质量,延长生存期。

Abstract

Objective:To observe the clinical efficacy of Modified Weichang’an Decoction combined with 5-fluorouracil based chemotherapy in treating elderly patients with stage Ⅳ colorectal cancer. Methods 133 elderly patients with stage Ⅳ colorectal cancer were divided into the treatment group (68 cases) and control group (65 cases). All patients were treated with 5-fluorouracil based chemotherapy for 3 courses. In addition,the treatment group was orally treated with Modified Weichang’an Decoction. The short-term efficacy,toxic and adverse reactions,quality of life and overall survival in the two groups were compared. Results:①In short-term efficacy,there were no statistically significant differences on the total effective rate and disease control rate between the two groups(P>0.05). ②The life quality of patients in the treatment group was better than that in the control group(P<0.01). ③The median PFS and median OS in the treatment group were significantly longer than those in the control group(P<0.05). ④The toxic and adverse reactions such as leukocyte reduction and peripheral neurotoxicity in the treatment group were less than those in the control group(P<0.05,P<0.01). Conclusion: Modified Weichang’an Decoction combined with 5-fluorouracil based chemotherapy can enhance the short-term efficacy,reduce the toxic and adverse reactions,improve the life quality and prolong the survival in treating elderly patients with stage Ⅳ colorectal cancer.

关键词

结直肠癌胃肠安方生活质量生存期老年

Keywords

colorectal cancerWeichang’an Decoctionquality of lifeoverall survivalelderly

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