Influence of Yiwei Xiaoai Decoction combined with OLF chemotherapy on life quality and immune function of patients with advanced gastric cancer

HUANG Mei-qin; SHI Zhi-qin; DING Gang; GAO Zhi-sheng; MA Zhi-heng; HUANG Qian

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Influence of Yiwei Xiaoai Decoction combined with OLF chemotherapy on life quality and immune function of patients with advanced gastric cancer

更新时间：2022-08-31

- Influence of Yiwei Xiaoai Decoction combined with OLF chemotherapy on life quality and immune function of patients with advanced gastric cancer
- Shanghai Journal of Traditional Chinese Medicine Vol. 51, Issue 6, Pages: 49-51(2017)
- 作者机构：
  
  1. 上海交通大学医学院附属新华医院崇明分院,上海,202150
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HUANG Mei-qin, SHI Zhi-qin, DING Gang, et al. Influence of Yiwei Xiaoai Decoction combined with OLF chemotherapy on life quality and immune function of patients with advanced gastric cancer. [J]. Shanghai Journal of Traditional Chinese Medicine 51(6):49-51(2017)
DOI：

HUANG Mei-qin, SHI Zhi-qin, DING Gang, et al. Influence of Yiwei Xiaoai Decoction combined with OLF chemotherapy on life quality and immune function of patients with advanced gastric cancer. [J]. Shanghai Journal of Traditional Chinese Medicine 51(6):49-51(2017) DOI：

摘要

目的：观察益胃消癌汤联合OLF化疗方案对进展期胃癌患者生活质量及免疫功能的影响。方法：将84例进展期胃癌拟行化疗患者随机分为对照组(41例)和中药组(43例),两组均予OLF化疗方案,中药组同时加服益胃消癌汤；3个周期后,观察两组主要中医证候积分、生活质量核心量表(QLQ-C30量表)积分及免疫功能(CD3,+,、CD4,+,、CD8,+,)的变化情况。结果：①治疗前后组内比较,中药组胃脘疼痛、食少纳呆、胃气上逆、乏力懒言、消瘦积分及总积分差异均有统计学意义(P,<,0.05),对照组胃脘疼痛、食少纳呆、胃气上逆、乏力懒言积分及总积分差异有统计学意义(P,<,0.05)；组间治疗后比较,各项证候积分及总积分差异均有统计学意义(P,<,0.05)。②治疗前后组内比较,中药组QLQ-C30量表中躯体功能、情绪功能、认知功能及整体生活质量积分差异有统计学意义(P,<,0.05),对照组仅认知功能、整体生活质量积分差异有统计学意义(P,<,0.05)；组间治疗后比较,躯体功能、情绪功能、认知功能及整体生活质量积分差异有统计学意义(P,<,0.05)。③治疗前后组内比较,中药组CD3,+,、CD4,+,、CD8,+,、CD4,+,/CD8,+,差异均有统计学意义(P,<,0.05),对照组仅CD3,+,差异有统计学意义(P,<,0.05)；组间治疗后比较,各指标差异均有统计学意义(P,<,0.05)。结论：益胃消癌汤联合OLF化疗方案,可明显改善进展期胃癌患者的生活质量,提高免疫功能。

Abstract

Objective:To observe the influence of Yiwei Xiaoai Decoction combined with OLF chemotherapy on life quality and immune function of patients with advanced gastric cancer. Methods 84 patients with advanced gastric cancer were randomly divided into the control group(41 cases)and Chinese medicine group(43 cases). Both groups were given OLF chemotherapy,and the Chinese medicine group was treated with Yiwei Xiaoai Decoction additionally. After 3 cycles of chemotherapy,the changes of main TCM syndrome scores,scores of life quality in QLQ-C30 scale and immune function(CD3,+,CD4,+,CD8,+,)in both groups were observed. Results:①For the comparison between treatment before and after,there were statistically significant differences on the syndrome scores of epigastric pain,eating less and anorexia,adverse ascending of stomach qi,weakness and laziness to speak and the total score in the two groups(P,<,0.05), and there was statistically significant difference on the syndrome score of marasmus in Chinese medicine group(P,<,0.05). For the comparison after treatment,there were statistically significant differences on all the syndrome scores and the total score between the two groups(P,<,0.05).②For the comparison between treatment before and after,there were statistically significant differences on the scores of physical function,emotional function,cognitive function and overall life quality in Chinese medicine group(P,<,0.05),there were statistically significant differences on the scores of cognitive function and overall life quality in the control group(P,<,0.05). For the comparison after treatment,there were statistically significant differences on the scores of physical function,emotional function,cognitive function and overall life quality between the two groups(P,<,0.05).③For the comparison between treatment before and after,there were statistically significant differences on the levels of CD3,+,CD4,+,CD8,+, and CD4,+,/CD8,+in, Chinese medicine group(P,<,0.05),there was statistically significant difference on the level of CD3,+in, the control group(P,<,0.05). For the comparison after treatment,there were statistically significant differences on the levels of CD3,+,CD4,+,CD8,+, and CD4,+,/CD8,+bet,ween the two groups(P,<,0.05). Conclusion: Yiwei Xiaoai Decoction combined with OLF chemotherapy can significantly improve the life quality of patients with advanced gastric cancer,and enhance the immune function.

关键词

进展期胃癌益胃消癌汤化学疗法生活质量免疫功能

Keywords

advanced gastric cancerYiwei Xiaoai Decoctionchemotherapylife qualityimmune function

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