Clinical observation of No.1 Tangshen Decoction in treating patients of stage Ⅲdiabetic nephropathy with syndrome of qi-yin deficiency

CHU Jin; HE Li-qun

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Clinical observation of No.1 Tangshen Decoction in treating patients of stage Ⅲdiabetic nephropathy with syndrome of qi-yin deficiency

更新时间：2022-08-31

- Clinical observation of No.1 Tangshen Decoction in treating patients of stage Ⅲdiabetic nephropathy with syndrome of qi-yin deficiency
- Shanghai Journal of Traditional Chinese Medicine Vol. 51, Issue 6, Pages: 56-59(2017)
- 作者机构：
  
  1. 上海市静安区闸北中心医院中医内科,上海,200070
  2. 上海中医药大学附属曙光医院肾病科,上海,200021
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CHU Jin, HE Li-qun. Clinical observation of No.1 Tangshen Decoction in treating patients of stage Ⅲdiabetic nephropathy with syndrome of qi-yin deficiency. [J]. Shanghai Journal of Traditional Chinese Medicine 51(6):56-59(2017)
DOI：

CHU Jin, HE Li-qun. Clinical observation of No.1 Tangshen Decoction in treating patients of stage Ⅲdiabetic nephropathy with syndrome of qi-yin deficiency. [J]. Shanghai Journal of Traditional Chinese Medicine 51(6):56-59(2017) DOI：

摘要

目的：观察糖肾1号方结合西医常规疗法治疗气阴两虚型Ⅲ期糖尿病肾病的临床疗效。方法：将60例气阴两虚型Ⅲ期糖尿病肾病患者随机分为治疗组和对照组,每组30例。两组均予西医常规疗法,治疗组在此基础上加服糖肾1号方。两组疗程均为3个月,观察临床疗效,比较中医证候积分及尿白蛋白排泄率(UAE)、血肌酐(Scr)、糖化血红蛋白(HbA1c)、纤维蛋白原降解产物(FDP)、总胆固醇(TC)、三酰甘油(TG)等生化指标的变化情况。结果：①治疗组、对照组临床总有效率分别为86.67%、60.00%；组间临床疗效比较,治疗组明显优于对照组(P<0.05)。②组间治疗前后中医证候积分差值比较,差异有统计学意义,治疗组中医证候积分改善程度比对照组更加显著(P<0.05)。③组间治疗后比较,UAE、TG及FDP水平差异有统计学意义(P<0.05)。结论：糖肾1号方可改善气阴两虚型糖尿病肾病Ⅲ期患者的临床症状、降低尿微量白蛋白,其机制可能与调节脂质代谢、改善肾脏血流动力学有关。

Abstract

Objective:To observe the clinical efficacy of No.1 Tangshen Decoction combined with routine therapy of western medicine in treating diabetic nephropathy of stage Ⅲ with syndrome of qi-yin deficiency. Methods Sixty patients of stage Ⅲ diabetic nephropathy with syndrome of qi-yin deficiency were randomly divided into the treatment group and control group,30 cases in each group. Both groups were treated with routine therapy of western medicine,and the treatment group was treated with No.1 Tangshen Decoction additionally,with a course of 3 months. The clinical efficacy was observed,and the changes of TCM syndrome score,urinary albumin excretion rate (UAE),serum creatinine (Scr),glycosylated hemoglobin (HbA1c),fibrinogen degradation products (FDP),total cholesterol (TC) and triacylglycerol(TG)were compared. Results: ①The clinical total effective rate was 86.67% in the treatment group and 60.00% in the control group. The clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05). ②For the comparison of the difference of TCM syndrome score between treatment before and after,there was statistically significant difference between the two groups. The improvement on TCM syndrome score in the treatment group was more significant than that in the control group(P<0.05). ③After treatment,there were statistically significant differences on the levels of UAE,TG and FDP between the two groups(P<0.05). Conclusion: No.1 Tangshen Decoction can improve the clinical symptoms of patients of stage Ⅲ diabetic nephropathy with syndrome of qi-yin deficiency,and decrease the urinary microalbumin. Its mechanism may be related to regulating lipid metabolism and improving renal hemodynamics.

关键词

糖尿病肾病糖肾1号方气阴两虚瘀血阻络糖脂代谢紊乱

Keywords

diabetic nephropathyNo.1 Tangshen Decoctionqi-yin deficiencycollaterals obstruction by blood stasisglucose and lipid metabolism disorder

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