Clinical observation of Xiaoying Mixture combined with glucocorticoid in the treatment of thyroid associated opthalmopathy above active stage III grade

SHI Jing-lin; PING Jian

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Clinical observation of Xiaoying Mixture combined with glucocorticoid in the treatment of thyroid associated opthalmopathy above active stage III grade

更新时间：2022-08-31

- Clinical observation of Xiaoying Mixture combined with glucocorticoid in the treatment of thyroid associated opthalmopathy above active stage III grade
- Shanghai Journal of Traditional Chinese Medicine Vol. 51, Issue 6, Pages: 63-66(2017)
- 作者机构：
  
  1. 上海中医药大学附属曙光医院眼科,上海,201203
  2. 上海中医药大学附属曙光医院中医临床重点实验室,上海,201203
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SHI Jing-lin, PING Jian. Clinical observation of Xiaoying Mixture combined with glucocorticoid in the treatment of thyroid associated opthalmopathy above active stage III grade. [J]. Shanghai Journal of Traditional Chinese Medicine 51(6):63-66(2017)
DOI：

SHI Jing-lin, PING Jian. Clinical observation of Xiaoying Mixture combined with glucocorticoid in the treatment of thyroid associated opthalmopathy above active stage III grade. [J]. Shanghai Journal of Traditional Chinese Medicine 51(6):63-66(2017) DOI：

摘要

目的：观察消瘿合剂联合糖皮质激素治疗活动期Ⅲ级以上甲状腺相关性眼病(TAO)的临床疗效。方法：将60例活动期Ⅲ级以上甲状腺相关性眼病患者随机分为治疗组与对照组,每组30例。两组均予甲强龙激素冲击疗法,同时治疗组予消瘿合剂口服,对照组予消瘿合剂安慰剂口服。两组疗程均为3个月,观察临床疗效,比较甲状腺相关性眼病病情分级(NOSPECS)、疾病活动度评分(CAS)的变化情况。结果：①治疗组、对照组临床总有效率分别为93.33%和83.33%；组间临床疗效比较,治疗组明显优于对照组(P<0.05)。②组间治疗后NOSPECS病情分级比较,治疗组较对照组改善更加明显(P<0.05)。③治疗前后组内比较,两组CAS临床活动度评分差异均有统计学意义(P<0.05)；组间治疗前后CAS临床活动度评分差值比较,治疗组明显高于对照组(P<0.05)。结论：与单纯激素冲击疗法相比,联用消瘿合剂能更加明显地缓解活动期Ⅲ级以上TAO患者的临床症状,控制病情进展。

Abstract

Objective:To observe the clinical efficacy of Xiaoying Mixture combined with glucocorticoid in the treatment of thyroid associated opthalmopathy(TAO)above active stage III grade. Methods Sixty patients with TAO above active stage III grade were randomly divided into the treatment group and control group,30 cases in each group. Both groups were treated with stosstherapy of methylprednisolone. Meanwhile,the treatment group was orally treated with Xiaoying Mixture and the control group was orally treated with the placebo,with a course of 3 months. The clinical efficacy was observed,and the changes of NOSPECS grades and clinical activity scale(CAS)score were compared. Results: ①The clinical total effective rate of the treatment group and control group was 93.33% and 83.33% respectively. The clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05).②After treatment,the improvement on NOSPECS grades in the treatment group was more significant than that in the control group(P<0.05).③For the comparison between treatment before and after,the differences on CAS score was statistically significant in both groups(P<0.05).For the comparison of the difference of CAS score before and after treatment,the difference in the treatment group was significantly higher than that in the control group(P<0.05). Conclusion: Compared with the single glucocorticoid stosstherapy,Xiaoying Mixture combined with glucocorticoid can more significantly alleviate the clinical symptoms of patients with TAO above active stage III grade and control the disease development.

关键词

甲状腺相关性眼病瘿病鹘眼凝睛消瘿合剂激素冲击疗法安慰剂

Keywords

thyroid associated ophthalmopathygoiterexophthalmosXiaoying Mixturehormone stosstherapyplacebo

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