Clinical observation of Sanqi Decoction in the prevention and treatment of myelosuppression induced by chemotherapy in non-small cell lung cancer with syndrome of qi and yin deficiency

GU Fang-hong; ZHANG Xiang

您当前的位置：

首页 >

文章列表页 >

Clinical observation of Sanqi Decoction in the prevention and treatment of myelosuppression induced by chemotherapy in non-small cell lung cancer with syndrome of qi and yin deficiency

更新时间：2022-08-31

- Clinical observation of Sanqi Decoction in the prevention and treatment of myelosuppression induced by chemotherapy in non-small cell lung cancer with syndrome of qi and yin deficiency
- Shanghai Journal of Traditional Chinese Medicine Vol. 51, Issue 5, Pages: 39-41(2017)
- 作者机构：
  
  1. 复旦大学附属中山医院青浦分院中医科,上海,201700
- 作者简介：
- 基金信息：
- DOI：
  CLC：
扫描看全文
GU Fang-hong, ZHANG Xiang. Clinical observation of Sanqi Decoction in the prevention and treatment of myelosuppression induced by chemotherapy in non-small cell lung cancer with syndrome of qi and yin deficiency. [J]. Shanghai Journal of Traditional Chinese Medicine 51(5):39-41(2017)
DOI：

GU Fang-hong, ZHANG Xiang. Clinical observation of Sanqi Decoction in the prevention and treatment of myelosuppression induced by chemotherapy in non-small cell lung cancer with syndrome of qi and yin deficiency. [J]. Shanghai Journal of Traditional Chinese Medicine 51(5):39-41(2017) DOI：

摘要

目的：观察三奇汤防治气阴两虚型非小细胞肺癌化疗后骨髓抑制的临床疗效。方法：将60例气阴两虚型非小细胞肺癌患者随机分成治疗组和对照组,每组30例。对照组予以含铂化疗方案,治疗组在化疗基础上加服中药三奇汤。两组化疗疗程均为6周,治疗组提前1周开始服中药(即疗程为7周)。观察骨髓抑制发生率及分级情况,比较血清粒巨噬细胞集落刺激因子(GM-CSF)及生活质量评分(KPS)的变化情况。结果：①组间骨髓抑制率比较,治疗组较对照组明显更低(P<0.05)。治疗组WBC、RBC、PLT及NEUT的Ⅰ、Ⅱ度毒性反应发生率均明显少于对照组(P<0.05)。②组间治疗后比较,治疗组GM-CSF水平明显高于对照组(P<0.05)。③组间比较,治疗组KPS提高率及稳定率均明显优于对照组(P<0.05)。结论：三奇汤防治气阴两虚型非小细胞肺癌化疗后骨髓抑制效果显著,且可调节相关细胞因子浓度,改善患者的生活质量。

Abstract

Objective:To observe the clinical efficacy of Sanqi Decoction in the prevention and treatment of myelosuppression induced by chemotherapy in non-small cell lung cancer with syndrome of qi and yin deficiency. Methods60 patients of non-small cell lung cancer with syndrome of qi and yin deficiency were randomly divided into the treatment group and control group,30 case in each group. The control group was treated with platinum chemotherapy,and the treatment group was treated with Sanqi Decoction additionally based on chemotherapy. The chemotherapy course of both groups were 6 weeks,and Sanqi Decoction was given one week in advance(a course of 7 weeks in the treatment group).The incidence and classification of myelosuppression were observed,and the serum level of granulocyte macrophage colony stimulating factor (GM-CSF) and Karnofsky performance scores(KPS)were compared. Results:①The incidence rate of myelosuppression in the treatment group was significantly lower than that in the control group(P<0.05).The incidence rates of toxic reaction with I,II degree on white blood cell (WBC),red blood cell (RBC),platelet (PLT) and neutrophil(NEUT) were significantly lower than those in the control group(P<0.05). ②After treatment,the level of GM-CSF in the treatment group was significantly higher than that in the control group(P<0.05). ③After treatment,the improvement and stability of KPS in the treatment group were significantly better than those in the control group(P<0.05). Conclusion:Sanqi Decoction shows significant efficacy in the prevention and treatment of myelosuppression induced by chemotherapy in non-small cell lung cancer with syndrome of qi and yin deficiency,which can regulate the related cytokine concentration and improve the life quality of patients.

关键词

非小细胞肺癌化疗骨髓抑制气阴两虚三奇汤减毒增效何承志

Keywords

non small cell lung cancerchemotherapymyelosuppressionsyndrome of qi and yin deficiencySanqi Decoctionreducing toxicity and enhancing efficacyHe Chengzhi

references

Views

202

下载量

CSCD

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

Clinical study of Bazhen Decoction combined with decitabine and CAG chemotherapy in the treatment of elderly acute myeloid leukemia

Short term efficacy observation of Shidao Tongjie Granule combined with chemotherapy in the treatment of advanced esophageal cancer

Clinical observation of the effects of Fuzheng Guben RecipeⅠon the immune function and side reactions of chemotherapy in patients of advanced non small cell lung cancer with syndrome of lung and spleen deficiency

Based on theory of “all cold with contraction belong to the kidney” to explore the treatment of myelosuppression after chemotherapy for gastric cancer from kidney

Pathogenetic characteristics and therapeutic countermeasures of traditional Chinese medicine for chemotherapy⁃induced thrombocytopenia

Related Author

No data

Related Institution

Department of Geriatric Respiratory Medicine, The First Affiliated Hospital of China Medical University

Department of Hematology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine

School of the First Clinical Medical Sciences, Liaoning University of Traditional Chinese Medicine

Graduate School,Medical College of Shanghai Jiao Tong University

Department of Integrated Chinese and Western Medicine,Shanghai Chest Hospital Affiliated to Shanghai Jiao Tong University

⁰