Research on hypoglycemic activity of Sophora japonica L. extract

ZHANG Wei-yun; WANG Li-rong; XU Chang-jiang; WANG Qing; ZHU Shan-shan; CHEN Quan-cheng

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Research on hypoglycemic activity of Sophora japonica L. extract

更新时间：2022-08-31

- Research on hypoglycemic activity of Sophora japonica L. extract
- Shanghai Journal of Traditional Chinese Medicine Vol. 51, Issue 5, Pages: 93-97(2017)
- 作者机构：
  
  1. 厦门医学院中心实验室、厦门市中药生物工程重点实验室、福建省中药精加工与健康产品开发重点研究室、福建省道地药材生物工程重点实验室、厦门医学院药学系,福建,厦门,361023
  2. 厦门大学药学院,福建,厦门,361102
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ZHANG Wei-yun, WANG Li-rong, XU Chang-jiang, et al. Research on hypoglycemic activity of Sophora japonica L. extract. [J]. Shanghai Journal of Traditional Chinese Medicine 51(5):93-97(2017)
DOI：

ZHANG Wei-yun, WANG Li-rong, XU Chang-jiang, et al. Research on hypoglycemic activity of Sophora japonica L. extract. [J]. Shanghai Journal of Traditional Chinese Medicine 51(5):93-97(2017) DOI：

摘要

目的：研究槐花Sophora japonica L.(Leguminosae)提取物对2型糖尿病小鼠降血糖活性。方法：通过超声提取法获得槐花乙醇提取物。使用腹腔注射烟碱和链脲霉素诱导的2型糖尿病小鼠模型和3T3-L1 前脂肪细胞分化模型,检测槐花乙醇提取物对小鼠血糖的影响和对3T3-L1 前脂肪细胞分化的影响。结果：槐花乙醇提取物灌胃剂量每日100 μg/g,连续灌胃给药3周,降低了2型糖尿病小鼠的血糖,改善口服葡萄糖耐受试验OGTT过程中的糖耐量。0.4 mg/L和0.8 mg/L的槐花乙醇提取物均能促进3T3-L1前脂肪细胞分化。结论：槐花乙醇提取物降低2型糖尿病小鼠血糖,促进3T3-L1前脂肪细胞分化,具体作用机制有待进一步研究。

Abstract

Objective:To investigate the hypoglycemic activity of Sophora japonica L. extract in mice with type 2 diabetes mellitus. MethodsEthanol extract of Sophora japonica L. was acquired by ultrasonic extraction. Mice model of type 2 diabetes mellitus induced by nicotinamide and streptozotocin with intraperitoneal injection and 3T3-L1 preadipocytes differentiation model were established to determine the effects of ethanol extract of Sophora japonica L. on blood glucose and 3T3-L1 preadipocytes differentiation. Results:After treatment with ethanol extract of Sophora japonica L. by intragastric administration at the daily dose of 100 μg/g for continuous 3 weeks,the level of blood glucose in type 2 diabetic mice was reduced,and the glucose tolerance in oral glucose tolerance test(OGTT)was improved. Differentiation of 3T3-L1 preadipocytes was promoted by ethanol extract at the concentration of 0.4 and 0.8 mg/L. Conclusion:Ethanol extract of Sophora japonica L. can reduce the blood glucose in type 2 diabetic mice and promote the differentiation of 3T3-L1 preadipocytes. The specific mechanism needs further study.

关键词

槐花2型糖尿病小鼠血糖3T3-L1前脂肪细胞分化

Keywords

Sophora japonica L.(Leguminosae)type 2 diabetic mellitusblood glucose3T3-L1 preadipocytesdifferentiation

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